Association of gliclazide and left ventricular mass in type 2 diabetic patients
Diabetes is a state of increased oxidant stress and there is evidence that oxidation may play a role in the genesis of higher left ventricular mass. Gliclazide has been shown to possess free radical scavenging properties. We assessed whether gliclazide may have a beneficial effect on left ventricula...
Saved in:
Published in | Diabetes research and clinical practice Vol. 74; no. 2; pp. 121 - 128 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.11.2006
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Diabetes is a state of increased oxidant stress and there is evidence that oxidation may play a role in the genesis of higher left ventricular mass. Gliclazide has been shown to possess free radical scavenging properties. We assessed whether gliclazide may have a beneficial effect on left ventricular mass via reducing 8-iso-prostaglandin F
2α concentrations, a reliable marker of oxidant injury. A total of 41 patients were randomized into two groups. All patients had been taking glibenclamide for more than 3 months before being randomized to switch either an equipotent dose of gliclazide (
n
=
21) or to continue on glibenclamide (
n
=
20). Baseline characteristics were similar in both groups. At 6 months, gliclazide-treated patients showed a significant regression in left ventricular mass index compared with the glibenclamide-treated group (−16% versus 3%,
P
=
0.003). Gliclazide patients had significantly lower plasma 8-iso-prostaglandin F
2α compared with baseline (299
±
101
pg/ml versus 400
±
112
pg/ml,
P
=
0.001) and the glibenclamide-treated patients (299
±
101
pg/ml versus 388
±
114
pg/ml,
P
=
0.01) after 6-month therapy. The magnitude of left ventricular mass index regression correlated univariately with the magnitude of inhibition of 8-iso-prostaglandin F
2α formation (
r
=
0.74,
P
<
0.0001). Multivariate analysis revealed that regression of left ventricular mass index significantly correlated with the changes of 8-iso-prostaglandin F
2α (
P
<
0.0001, adjusted
R
2
=
0.55). Our findings demonstrated for the first time that in addition to its primary hypoglycemia, gliclazide may have an additional effect on reducing left ventricular mass, possibly through attenuation of free radical formation. |
---|---|
Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
ISSN: | 0168-8227 1872-8227 |
DOI: | 10.1016/j.diabres.2006.03.009 |