Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy

An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with red...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 55; pp. 7621 - 7624
Main Authors Ling, Longbing, Yu, Haizhou, Ismail, Muhammad, Zhu, Yanping, Du, Yuan, Qi, Junhui
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 14.07.2020
Royal Society of Chemistry
Subjects
Animals
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Cancer
Cell Line, Tumor
Cell membranes
Cell Proliferation - drug effects
Chemistry
Chemistry, Multidisciplinary
Chemotherapy
Dimers
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug delivery systems
Female
Humans
Liposomes
Liposomes - chemical synthesis
Liposomes - chemistry
Liposomes - therapeutic use
Mice, Inbred BALB C
Neoplasms - drug therapy
Phosphatidylcholines - chemical synthesis
Phosphatidylcholines - chemistry
Phosphatidylcholines - therapeutic use
Phospholipids
Physical Sciences
Podophyllotoxin - analogs & derivatives
Podophyllotoxin - chemical synthesis
Podophyllotoxin - therapeutic use
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - therapeutic use
Science & Technology
Xenograft Model Antitumor Assays
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Abstract An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy. A liposomal platform self-assembled from a novel and universal synthetic dimeric-drug phospholipid.
AbstractList An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy.
An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy. A liposomal platform self-assembled from a novel and universal synthetic dimeric-drug phospholipid.
Author Ling, Longbing
Ismail, Muhammad
Qi, Junhui
Zhu, Yanping
Du, Yuan
Yu, Haizhou
AuthorAffiliation School of Pharmacy
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China)
Yantai University
Yantai Center for Food and Drug Control
Henan-Macquarie University Joint Center for Biomedical Innovation School of Life Science
Henan University
AuthorAffiliation_xml – name: Yantai University
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Snippet An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results...
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SubjectTerms Animals
Anticancer properties
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Cancer
Cell Line, Tumor
Cell membranes
Cell Proliferation - drug effects
Chemistry
Chemistry, Multidisciplinary
Chemotherapy
Dimers
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug delivery systems
Female
Humans
Liposomes
Liposomes - chemical synthesis
Liposomes - chemistry
Liposomes - therapeutic use
Mice, Inbred BALB C
Neoplasms - drug therapy
Phosphatidylcholines - chemical synthesis
Phosphatidylcholines - chemistry
Phosphatidylcholines - therapeutic use
Phospholipids
Physical Sciences
Podophyllotoxin - analogs & derivatives
Podophyllotoxin - chemical synthesis
Podophyllotoxin - therapeutic use
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - therapeutic use
Science & Technology
Xenograft Model Antitumor Assays
Title Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy
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Volume 56
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