Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy

• Published in: Chemical communications (Cambridge, England) Vol. 56; no. 55; pp. 7621 - 7624
• Main Authors: Ling, Longbing, Yu, Haizhou, Ismail, Muhammad, Zhu, Yanping, Du, Yuan, Qi, Junhui
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 14.07.2020; Royal Society of Chemistry
• Subjects: Animals; Anticancer properties; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Cancer; Cell Line, Tumor; Cell membranes; Cell Proliferation - drug effects; Chemistry; Chemistry, Multidisciplinary; Chemotherapy; Dimers; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug delivery systems; Female; Humans; Liposomes; Liposomes - chemical synthesis; Liposomes - chemistry; Liposomes - therapeutic use; Mice, Inbred BALB C; Neoplasms - drug therapy; Phosphatidylcholines - chemical synthesis; Phosphatidylcholines - chemistry; Phosphatidylcholines - therapeutic use; Phospholipids; Physical Sciences; Podophyllotoxin - analogs & derivatives; Podophyllotoxin - chemical synthesis; Podophyllotoxin - therapeutic use; Prodrugs - chemical synthesis; Prodrugs - chemistry; Prodrugs - therapeutic use; Science & Technology; Xenograft Model Antitumor Assays
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/d0cc03589k

An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy. A liposomal platform self-assembled from a novel and universal synthetic dimeric-drug phospholipid.