Enhanced mechanical and biological characteristics of PLLA composites through surface grafting of oligolactide on magnesium hydroxide nanoparticles

• Published in: Biomaterials science Vol. 8; no. 7; pp. 218 - 23
• Main Authors: Kang, Eun Young, Park, Sung-Bin, Choi, Bogyu, Baek, Seung-Woon, Ko, Kyoung-Won, Rhim, Won-Kyu, Park, Wooram, Kim, Ik-Hwan, Han, Dong Keun
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 31.03.2020
• Subjects: Acidification; Albumins; Biocompatibility; Biodegradability; Biomedical materials; Degradation; Fibrinogen; Grafting; Homogeneity; Hybrid composites; In vivo methods and tests; Magnesium hydroxide; Mechanical properties; Modulus of elasticity; Nanocomposites; Nanoparticles; Polylactic acid; Polymer matrix composites; Polymers; Surgical implants; Toxicity
• ISSN: 2047-4830; 2047-4849
• DOI: 10.1039/c9bm01863h

Poly( l -lactic acid) (PLLA) is a biocompatible and biodegradable polymer that has received much attention as a biomedical material. However, PLLA also produces by-products that acidify the surrounding tissues during in vivo degradation, which induces inflammatory responses. To overcome these problems, magnesium hydroxide nanoparticles (nano-magnesium hydroxide; nMH) were added to the PLLA matrix as a bioactive filler that can suppress inflammatory responses by neutralizing the acidified environment caused by the degradation of PLLA. Despite the advantages of nMH, the strong cohesion of these nanoparticles toward each other makes it difficult to manufacture a polymer matrix containing homogeneous nanoparticles through thermal processing. Here, we prepared two types of surface-modified nMH with oligolactide (ODLLA) utilizing grafting to (GT) and grafting from (GF) strategies to improve the mechanical and biological characteristics of the organic-inorganic hybrid composite. The incorporation of surface-modified nMH not only enhanced mechanical properties, such as Young's modulus, but also improved homogeneity of magnesium hydroxide particles in the PLLA matrix due to the increase in interfacial interaction. Additionally, the PLLA composites with surface-modified nMH exhibited reduced bulk erosion during hydrolytic degradation with lower cytotoxicity and immunogenicity. Hemocompatibility tests on the PLLA composites with nMH showed a higher albumin to fibrinogen ratio (AFR) and a lower influence of platelet activation, when compared with unmodified control samples. Taken all together, the surface-modified nMH could be seen to successfully improve the physical and biological characteristics of polymer composites. We believe this technology has great potential for the development of hybrid nanocomposites for biomedical devices, including cardiovascular implants. Surface-modified magnesium hydroxide (MH) was incorporated to not only improve physico-mechanical properties but also enhance biological properties of Poly( l -lactic acid) (PLLA) more effectively.