Self-assembled peptide-inorganic nanoparticle superstructures: from component design to applications
Peptides have become excellent platforms for the design of peptide-nanoparticle hybrid superstructures, owing to their self-assembly and binding/recognition capabilities. Morover, peptide sequences can be encoded and modified to finely tune the structure of the hybrid systems and pursue functionalit...
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| Published in | Chemical communications (Cambridge, England) Vol. 56; no. 58; pp. 8 - 814 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
25.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Peptides have become excellent platforms for the design of peptide-nanoparticle hybrid superstructures, owing to their self-assembly and binding/recognition capabilities. Morover, peptide sequences can be encoded and modified to finely tune the structure of the hybrid systems and pursue functionalities that hold promise in an array of high-end applications. This feature article summarizes the different methodologies that have been developed to obtain self-assembled peptide-inorganic nanoparticle hybrid architectures, and discusses how the proper encoding of the peptide sequences can be used for tailoring the architecture and/or functionality of the final systems. We also describe the applications of these hybrid superstructures in different fields, with a brief look at future possibilities towards the development of new functional hybrid materials.
Self-assembled peptide-nanoparticle superstructures, with tuned architectures and/or functionalities, hold great promise in multiple high-end applications. |
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| Bibliography: | Marcos D. García studied Chemistry at the Universidade de Santiago de Compostela, where he completed his PhD in 2005 under the supervision of Prof. F. Fernández and Prof. O. Caamaño. After post-doctoral studies at the University of Leicester with Prof. Paul R. Jenkins, in 2007 he moved back to Spain, joining the Universidade da Coruña as an Isidro Parga Pondal Fellow. Marcos currently holds a position at the UDC as Associate Professor, focusing his research interests on the field of molecular self-assembly, trying to find new ways to make heterocyclic compounds obey his will. Rosalía Sánchez-Fernández obtained her BSc degree in Biotechnology from the Universidad de Oviedo in 2018. The following year, she received her MSc degree in Supramolecular Chemistry from the Universidad de Salamanca. In 2020, Rosalía joined the Universidade da Coruña as a PhD student, where she is working under the supervision of Dr Elena Pazos and Prof. Carlos Peinador. Her research is focused on the development of metallopeptides to control the formation of nanostructures. Claudia Pigliacelli received her PhD in Pharmacy in 2015 from the University of East Anglia (UK). She has been working as a research assistant (2013-2015) and postdoctoral fellow (2015-2016) in the SupraBioNano Lab at the Politecnico di Milano (Italy), and in the Molecular Materials group in the Applied Physics Department of Aalto University (Finland, 2016-2019). In 2020 she joined the group of Elena Pazos at the Advanced Scientific Research Center (CICA). Her research interests include nanoparticle design and self-assembly, peptide and peptide-nanoparticle systems and in general nanomaterials for biomedical applications. Carlos Peinador studied chemistry at Universidade de Santiago de Compostela, receiving his PhD degree from the Universidade da Coruña where he has been working as Associate Professor from 2000 to 2018 and as Full Professor since 2018. His current research interests are oriented towards the field of Supramolecular Chemistry, with a particular focus on the use of 4,4′-bipyridinium-based cations for the self-assembly of catenanes and inclusion complexes and their implementation into stimuli-responsive supramolecular systems. He is the author of more than 100 research articles in peer-reviewed journals, and has written several Reviews and book chapters. Elena Pazos obtained her PhD in 2012 from the Universidade de Santiago de Compostela under the supervision of Prof. José L. Mascareñas and Prof. M. Eugenio Vázquez. In 2012 she received the Fundación Barrié Postdoctoral fellowship and joined Prof. Samuel I. Stupp at Northwestern University. She then joined Medcom Advance in 2014, and from December 2015 worked in the group of Prof. Ramón A. Álvarez-Puebla at Centre Tecnològic de la Química. In July 2017 she joined the Universidade da Coruña as an InTalent researcher, where her group is working on the development of new peptide-based materials and biosensors. |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/d0cc02914a |