Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of Nigrofomes melanoporus and their cytotoxicity

• Published in: Planta medica Vol. 78; no. 7; p. 737
• Main Authors: Chan, Hsiu-Hui, Juang, Shin-Hun, Thang, Tran Dinh, Chen, Min-Yu, Kuo, Ping-Chung, Yang, Mei-Lin, Ngan, Nguyen Thi, Linh, Nguyen Ngoc, Wu, Tian-Shung
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2012
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Cell Cycle - drug effects; Cell Line, Tumor; Coriolaceae - chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fruiting Bodies, Fungal - chemistry; Humans; Inhibitory Concentration 50; Jurkat Cells - drug effects; Lung Neoplasms - drug therapy; Molecular Conformation; Nasopharyngeal Neoplasms - drug therapy; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Sesquiterpenes - chemistry; Sesquiterpenes - isolation & purification; Sesquiterpenes - pharmacology; Vietnam; Vietnam
• ISSN: 1439-0221
• DOI: 10.1055/s-0031-1298367

Two new drimane-type compounds, nigrofomins A ( 1) and B ( 2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A ( 1) and B ( 2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC (50) values in the range of 99.44-246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G (0)/G (1) phase.