Theragnosis by a miR-141-3p molecular beacon: simultaneous detection and sensitization of 5-fluorouracil resistant colorectal cancer cells through the activation of the TRIM13-associated apoptotic pathway

We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 52; pp. 7466 - 7469
Main Authors Moon, Sung Ung, Park, Yongkeun, Park, Min Geun, Song, Sung Kyu, Jeong, Seok Hoo, Lee, Yong Seung, Heo, Hye Jung, Jung, Woon Yong, Kim, Soonhag
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 04.07.2019
Subjects
Cancer
Colorectal cancer
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Summary:We developed a molecular beacon targeting miR-141-3p, aberrantly increased in 5-fluorouracil-resistant colorectal cancer cells (R-CRCCs). It consists of a fluorophore-labeled oligonucleotide, antisense to miR-141-3p, and a quencher. It detected R-CRCCs and recovered the chemosensitivity of them to 5-fluorouracil by hybridization with miR-141-3p, which is applicable to cancer treatment. Schematic of the 'therapy and diagnosis at once (theragnosis)' for 5-FU resistant colorectal cancer using the miR-141-3p molecular beacon.
Bibliography:Electronic supplementary information (ESI) available: Experimental section, supplementary figures and tables. See DOI
10.1039/c9cc01944h
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc01944h