CORUM: the comprehensive resource of mammalian protein complexes--2009

CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (64%), mouse (16%) and rat (12%). Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions....

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Published inNucleic acids research Vol. 38; no. Database issue; pp. D497 - D501
Main Authors Ruepp, Andreas, Waegele, Brigitte, Lechner, Martin, Brauner, Barbara, Dunger-Kaltenbach, Irmtraud, Fobo, Gisela, Frishman, Goar, Montrone, Corinna, Mewes, H.-Werner
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2010
Subjects
Animals
Computational Biology - methods
Computational Biology - trends
Databases, Genetic
Databases, Protein
Humans
Information Storage and Retrieval - methods
Internet
Mice
Multiprotein Complexes
Phylogeny
Protein Structure, Tertiary
Rats
Saccharomyces cerevisiae - genetics
Software
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Summary:CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (64%), mouse (16%) and rat (12%). Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The new CORUM 2.0 release encompasses 2837 protein complexes offering the largest and most comprehensive publicly available dataset of mammalian protein complexes. The CORUM dataset is built from 3198 different genes, representing ~16% of the protein coding genes in humans. Each protein complex is described by a protein complex name, subunit composition, function as well as the literature reference that characterizes the respective protein complex. Recent developments include mapping of functional annotation to Gene Ontology terms as well as cross-references to Entrez Gene identifiers. In addition, a 'Phylogenetic Conservation' analysis tool was implemented that analyses the potential occurrence of orthologous protein complex subunits in mammals and other selected groups of organisms. This allows one to predict the occurrence of protein complexes in different phylogenetic groups. CORUM is freely accessible at (http://mips.helmholtz-muenchen.de/genre/proj/corum/index.html).
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ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkp914