Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice

• Published in: Oncogene Vol. 16; no. 1; pp. 61 - 68
• Main Authors: Blackshear, P E, Goldsworthy, S M, Foley, J F, McAllister, K A, Bennett, L M, Collins, N K, Bunch, D O, Brown, P, Wiseman, R W, Davis, B J
• Format: Journal Article
• Language: English
• Published: England 08.01.1998
• Subjects: Animals; BRCA2 Protein; Embryonic and Fetal Development - genetics; Female; Gene Expression Regulation, Developmental; Genes, BRCA1; In Situ Hybridization; Male; Mammary Glands, Animal - embryology; Mammary Glands, Animal - metabolism; Meiosis - genetics; Mice; Mitosis - genetics; Morphogenesis; Neoplasm Proteins - genetics; Ovary - metabolism; Pregnancy; Testis - embryology; Testis - metabolism; Transcription Factors - genetics

The mouse homologues of the breast cancer susceptibility genes, Brca1 and Brca2, are expressed in a cell cycle-dependent fashion in vitro and appear to be regulated by similar or overlapping pathways. Therefore, we compared the non isotopic in situ hybridization expression patterns of Brca1 and Brca...