BRAF Mutations in Hairy-Cell Leukemia

To the Editor: Tiacci et al. (June 16 issue) 1 report that the BRAF V600E mutation was present in all patients with hairy-cell leukemia (HCL) in their study. However, these findings should be interpreted with caution. Surprisingly, white-cell counts were elevated (>10,000 per cubic millimeter) in...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 365; no. 10; pp. 960 - 962
Main Authors Pardanani, Animesh, Tefferi, Ayalew
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 08.09.2011
Subjects
Antigens
CD103 antigen
CD11c antigen
CD25 antigen
Humans
Hypereosinophilic Syndrome - genetics
Leukemia
Leukemia, Hairy Cell - genetics
Leukemia, Myeloid - genetics
Lymphoma
Mastocytosis - genetics
Mutation
Myelodysplastic Syndromes - genetics
Pancytopenia
Proto-Oncogene Proteins B-raf - genetics
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Summary:To the Editor: Tiacci et al. (June 16 issue) 1 report that the BRAF V600E mutation was present in all patients with hairy-cell leukemia (HCL) in their study. However, these findings should be interpreted with caution. Surprisingly, white-cell counts were elevated (>10,000 per cubic millimeter) in 12 of the 48 patients, even though HCL is usually characterized by progressive pancytopenia. Moreover, immunostaining with the use of antiannexin A1 antibody, which is highly specific for HCL, 2 was not performed in 27 patients. The diagnosis of HCL was established mainly on the basis of the coexpression of CD11c, CD25, and CD103. 3 These antigens . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1108130