The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo
It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C ind...
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| Published in | Biochemical and biophysical research communications Vol. 186; no. 2; pp. 867 - 873 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
San Diego, CA
Elsevier
31.07.1992
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| Subjects | |
| Online Access | Get full text |
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| Abstract | It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C induced a transient decrease in blood pressure, followed by a long-lasting pressor response accompanied by a marked renal and mesenteric vasoconstriction. No constriction was observed in isolated mesenteric arteries in vitro, indicating that the in vivo vasoconstrictor effect is most likely indirect. The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1. |
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| AbstractList | It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still largely unknown. We used sarafotoxin S6C, a selective agonist of the ETB receptor, to study the in vivo effects of ETB stimulation. SRTX S6C induced a transient decrease in blood pressure, followed by a long-lasting pressor response accompanied by a marked renal and mesenteric vasoconstriction. No constriction was observed in isolated mesenteric arteries in vitro, indicating that the in vivo vasoconstrictor effect is most likely indirect. The pressor effect of SRTX S6C was not dependent on central stimulation of ETB receptors and was not mediated by catecholamines from the adrenal medulla, prostanoids or ET-1. |
| Author | LÖFFLER, B.-M CLOZEL, M GRAY, G. A OSTERWALDER, R BREU, V |
| Author_xml | – sequence: 1 givenname: M surname: CLOZEL fullname: CLOZEL, M organization: F. Hoffmann-La Roche Ltd, preclin. res., pharma div., 4002 Basel, Switzerland – sequence: 2 givenname: G. A surname: GRAY fullname: GRAY, G. A organization: F. Hoffmann-La Roche Ltd, preclin. res., pharma div., 4002 Basel, Switzerland – sequence: 3 givenname: V surname: BREU fullname: BREU, V organization: F. Hoffmann-La Roche Ltd, preclin. res., pharma div., 4002 Basel, Switzerland – sequence: 4 givenname: B.-M surname: LÖFFLER fullname: LÖFFLER, B.-M organization: F. Hoffmann-La Roche Ltd, preclin. res., pharma div., 4002 Basel, Switzerland – sequence: 5 givenname: R surname: OSTERWALDER fullname: OSTERWALDER, R organization: F. Hoffmann-La Roche Ltd, preclin. res., pharma div., 4002 Basel, Switzerland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5464614$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1323294$$D View this record in MEDLINE/PubMed |
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| Keywords | Vertebrata Mammalia Endothelin Rat Blood vessel Peptide hormone Rodentia Vasoconstriction Biological activity Vasodilation Hormonal receptor |
| Language | English |
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| References | Nagase (10.1016/0006-291X(92)90826-7_BIB17) 1990; 168 Williams (10.1016/0006-291X(92)90826-7_BIB6) 1991; 175 Warner (10.1016/0006-291X(92)90826-7_BIB5) 1989; 159 Williams (10.1016/0006-291X(92)90826-7_BIB10) 1991; 180 Sakurai (10.1016/0006-291X(92)90826-7_BIB2) 1990; 348 Terashita (10.1016/0006-291X(92)90826-7_BIB16) 1989; 45 Clozel (10.1016/0006-291X(92)90826-7_BIB18) 1989; 250 Takayanagi (10.1016/0006-291X(92)90826-7_BIB4) 1991; 282 Saeki (10.1016/0006-291X(92)90826-7_BIB7) 1991; 179 Shichiri (10.1016/0006-291X(92)90826-7_BIB14) 1989; 163 Wilkes (10.1016/0006-291X(92)90826-7_BIB13) 1991; 256 Gardiner (10.1016/0006-291X(92)90826-7_BIB19) 1989; 13 Lin (10.1016/0006-291X(92)90826-7_BIB3) 1991; 88 Yoshimoto (10.1016/0006-291X(92)90826-7_BIB20) 1991; 17 Randall (10.1016/0006-291X(92)90826-7_BIB11) 1989; 98 Mulvany (10.1016/0006-291X(92)90826-7_BIB8) 1977; 41 Arai (10.1016/0006-291X(92)90826-7_BIB1) 1990; 348 Ihara (10.1016/0006-291X(92)90826-7_BIB9) 1991; 50 Douglas (10.1016/0006-291X(92)90826-7_BIB12) 1991; 104 Kawaguchi (10.1016/0006-291X(92)90826-7_BIB15) 1990; 22 |
| References_xml | – volume: 41 start-page: 19 year: 1977 ident: 10.1016/0006-291X(92)90826-7_BIB8 publication-title: Circ. Res doi: 10.1161/01.RES.41.1.19 contributor: fullname: Mulvany – volume: 98 start-page: 685 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB11 publication-title: Br. J. Pharmacol doi: 10.1111/j.1476-5381.1989.tb12644.x contributor: fullname: Randall – volume: 22 start-page: 839 year: 1990 ident: 10.1016/0006-291X(92)90826-7_BIB15 publication-title: J. Mol. Cell. Cardiol doi: 10.1016/0022-2828(90)90115-I contributor: fullname: Kawaguchi – volume: 50 start-page: 247 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB9 publication-title: Life Sci doi: 10.1016/0024-3205(92)90331-I contributor: fullname: Ihara – volume: 348 start-page: 732 year: 1990 ident: 10.1016/0006-291X(92)90826-7_BIB2 publication-title: Nature doi: 10.1038/348732a0 contributor: fullname: Sakurai – volume: 168 start-page: 485 year: 1990 ident: 10.1016/0006-291X(92)90826-7_BIB17 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(90)92347-3 contributor: fullname: Nagase – volume: 13 start-page: S202 issue: Suppl. 5 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB19 publication-title: J. Cardiovasc. Pharmacol doi: 10.1097/00005344-198900135-00057 contributor: fullname: Gardiner – volume: 348 start-page: 730 year: 1990 ident: 10.1016/0006-291X(92)90826-7_BIB1 publication-title: Nature doi: 10.1038/348730a0 contributor: fullname: Arai – volume: 163 start-page: 1332 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB14 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(89)91124-8 contributor: fullname: Shichiri – volume: 17 start-page: S260 issue: Suppl. 7 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB20 publication-title: J. Cardiovasc. Pharmacol doi: 10.1097/00005344-199100177-00074 contributor: fullname: Yoshimoto – volume: 180 start-page: 475 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB10 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/S0006-291X(05)81089-7 contributor: fullname: Williams – volume: 159 start-page: 325 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB5 publication-title: Eur. J. Pharmacol doi: 10.1016/0014-2999(89)90167-2 contributor: fullname: Warner – volume: 175 start-page: 556 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB6 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(91)91601-8 contributor: fullname: Williams – volume: 282 start-page: 103 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB4 publication-title: FEBS Letters doi: 10.1016/0014-5793(91)80454-B contributor: fullname: Takayanagi – volume: 45 start-page: 1911 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB16 publication-title: Life Sci doi: 10.1016/0024-3205(89)90545-6 contributor: fullname: Terashita – volume: 88 start-page: 3185 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB3 contributor: fullname: Lin – volume: 250 start-page: 1125 year: 1989 ident: 10.1016/0006-291X(92)90826-7_BIB18 publication-title: J. Pharmacol. Exp. Ther contributor: fullname: Clozel – volume: 179 start-page: 286 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB7 publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/0006-291X(91)91367-L contributor: fullname: Saeki – volume: 104 start-page: 311 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB12 publication-title: Br. J. Pharmacol doi: 10.1111/j.1476-5381.1991.tb12428.x contributor: fullname: Douglas – volume: 256 start-page: 628 year: 1991 ident: 10.1016/0006-291X(92)90826-7_BIB13 publication-title: J. Pharmacol. Exp. Ther contributor: fullname: Wilkes |
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| Snippet | It has been suggested that the endothelin (ET) ETB receptor could mediate endothelium-dependent vasodilation to ET-1 or ET-3, but its in vivo role is still... |
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| SubjectTerms | Animals Biological and medical sciences Blood Pressure - drug effects Blood vessels and receptors Decerebrate State Endothelins - pharmacology Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Heart Rate - drug effects In Vitro Techniques Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology Methoxamine - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Rats Rats, Inbred Strains Receptors, Cell Surface - drug effects Receptors, Cell Surface - physiology Receptors, Endothelin Regional Blood Flow - drug effects Renal Circulation - drug effects Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vertebrates: cardiovascular system Viper Venoms - pharmacology |
| Title | The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo |
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