Influence of Three Different Diet Modes Combined with Exercise Loads on Urinary and Plasma Neopterin Concentrations: A Longitudinal Study

• Published in: Pteridines Vol. 8; no. 3; pp. 211 - 215
• Main Authors: Lamprecht, Manfred, Mlekusch, Walter, Vrecko, Karoline, Reibnegger, Gilbert
• Format: Journal Article
• Language: English
• Published: De Gruyter 01.09.1997
• Subjects: Diet; Exercise; Neopterin; Supplementation
• ISSN: 0933-4807; 2195-4720
• DOI: 10.1515/pteridines.1997.8.3.211

During six months, we studied the influence of three extremely different diet modes (normal diet, carbohydrate- rich diet, fat-rich diet) combined with three defined exercise loads (step test, endurance test fo r 30 minutes, endurance test for 90 minutes) on daily urinary neopterin concentrations of one voluntary subject. Furthermore, plasma and after each exercist: Each diet period lasted for 28 days and was performed twice : once without, and once with extra supplementation of antioxidants. Urinary neopterin concentrations showed a markedly high daily fluctuation, and there were three occasions with infectious complications which were accompanied by significantly raised uiinary neopterin. Howevt:r, when comparing neopterin levels grouped according to diet mode, absolutely no difference was found. Similarly, neither had supplementation an influence on neopterin, nor could coherent effects of the exercise loads on neopterin be detected. While plasma neopterin concentrations were significantly higher during exercise loads than before and after, the increase was small (about I nmol/l) and might have been due to slight alterations of renal function and/or hemodynamics during the physical exercise . Our study supports the robustness of the immune activation marker neopterin since no influences of these truly extreme diet modes on urinary and plasma neopterin could be detected, and exercise loads had no appreciable influence on urinary as well as plasma neopterin concentrations.