Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging

A stimuli-responsive fluorophore, encompassing a Lewis acid-base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. The fluorophore switches conformation, exhibiting different emission color and lifetimes, allowing for the detect...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 56; no. 44; pp. 5981 - 5984
Main Authors Arsenault, Nicole E, Downey, Kathleen T, Wolf, Michael O
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 02.06.2020
Royal Society of Chemistry
Subjects
Amines
Chemistry
Chemistry, Multidisciplinary
Drug carriers
Drug Carriers - chemistry
Fluorescence
Fluorescent Dyes - chemistry
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Lewis acid
Lewis Acids - chemistry
Moisture content
Nanoparticles
Nanoparticles - chemistry
Optical Imaging
Physical Sciences
Porosity
Science & Technology
Silicon dioxide
Silicon Dioxide - chemistry
Stimuli
Structural analysis
Switches
DESIGN
DYES
DRUG-DELIVERY
SILICA NANOPARTICLES
NANOMEDICINE
MEMBRANES
SENSORS
CANCER-THERAPY
Online AccessGet full text

Cover

More Information
Summary:A stimuli-responsive fluorophore, encompassing a Lewis acid-base pair, binds to primary amines on mesoporous silica nanoparticles, which may serve as environment-sensitive drug carriers. The fluorophore switches conformation, exhibiting different emission color and lifetimes, allowing for the detection of the water content of the nanoparticles' surroundings through fluorescence spectroscopy and microscopy. Environment-responsive fluorophores are attached to mesoporous silica nanoparticles that can be used for sensing water concentration around biologically-relevant substrates.
Bibliography:Electronic supplementary information (ESI) available: Synthetic procedures, structural characterization methods, structural characterization data, additional photophysical data. See DOI
10.1039/d0cc01203c
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01203c