ZnSe-based highly-sensitive SPR biosensor for detection of different cancer cells and urine glucose levels

• Published in: Optical and quantum electronics Vol. 55; no. 1
• Main Authors: El-assar, Mohamed, Taha, Taha E., El-Samie, Fathi E. Abd, Fayed, Heba A., Aly, Moustafa H.
• Format: Journal Article
• Language: English
• Published: New York Springer US 2023; Springer Nature B.V
• Subjects: Biosensors; Cancer; Characterization and Evaluation of Materials; Computer Communication Networks; Electrical Engineering; Glucose; Lasers; Optical Devices; Optics; Photonics; Physics; Physics and Astronomy; Semiconductor materials; Sensitivity enhancement; Urine; Zinc selenide; Surface plasmon resonance (SPR); Biosensors; Cancer cell detection; ZnSe; Glucose level detection
• ISSN: 0306-8919; 1572-817X
• DOI: 10.1007/s11082-022-04326-y

As detection of cancer and diabetes diseases has captured a great attention in the field of biosensing, many ways were introduced to detect these diseases with high accuracy. This paper presents a novel use of zinc selenide (ZnSe) semiconductor material to enhance the sensitivity of a conventional Ag-based surface plasmon resonance biosensor. The proposed sensor structure is simple (BK7 prism/Ag/ZnSe), cost-effective, and easy to design and fabricate. The sensor is tested in the detection of different cancerous cells in human blood, showing an excellent sensitivity of 359 ∘ /RIU. In addiion, it is tested to detect various glucose levels in human urine, and it provides a very high performance with a sensitivity of 366.6 ∘ /RIU, which is 70% better than that of a similar reported work. Thus, the proposed biosensor is capable efficiently to detect various kinds of cancer cells and different glucose concentrations in urine.