Role of 5′AMP-activated protein kinase in skeletal muscle

5′AMP-activated protein kinase (AMPK) is recognized as an important intracellular energy sensor, shutting down energy-consuming processes and turning on energy-generating processes. Discovery of target proteins of AMPK has dramatically increased in the past 10 years. Historically, AMPK was first sho...

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Bibliographic Details
Published inInternational Journal of Obesity Vol. 32; no. S4; pp. S13 - S17
Main Authors Treebak, J T, Wojtaszewski, J F P
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2008
Nature Publishing Group
Subjects
Antidiabetics
Cholesterol
Diabetes
Energy
Epidemiology
Exercise
Fatty acids
Health Promotion and Disease Prevention
Insulin resistance
Internal Medicine
Kinases
Medicine
Medicine & Public Health
Metabolic Diseases
Musculoskeletal system
Phosphorylation
Physical fitness
Physiology
Proteins
Public Health
review
Roles
Denmark
insulin sensitivity
AMPK
contraction
exercise
energy balance
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Summary:5′AMP-activated protein kinase (AMPK) is recognized as an important intracellular energy sensor, shutting down energy-consuming processes and turning on energy-generating processes. Discovery of target proteins of AMPK has dramatically increased in the past 10 years. Historically, AMPK was first shown to regulate fatty acid and cholesterol synthesis, but is now hypothesized to take part in the regulation of energy/fuel balance not only at the cellular level but also at the level of the whole organism. In this brief review we will discuss some of the roles of AMPK in skeletal muscle.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2008.117