An isomerization-ring-closing metathesis strategy for the synthesis of substituted benzofurans

Twelve substituted benzofurans were synthesized from their corresponding substituted 1-allyl-2-allyloxybenzenes using ruthenium-mediated C- and O-allyl isomerization followed by ring-closing metathesis. Twelve substituted benzofurans were synthesized from their corresponding substituted 1-allyl-2-al...

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Bibliographic Details
Published inTetrahedron Vol. 61; no. 32; pp. 7746 - 7755
Main Authors van Otterlo, Willem A.L., Morgans, Garreth L., Madeley, Lee G., Kuzvidza, Samuel, Moleele, Simon S., Thornton, Natalie, de Koning, Charles B.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 08.08.2005
Elsevier
Subjects
Benzofurans
Chemistry
Chemistry, Organic
Isomerization
Physical Sciences
Ring-closing metathesis
Science & Technology
Benzofurans
Ring-closing metathesis
Isomerization
ALLYL-ARYL ETHERS
CATALYSIS
isomerization
ANALOGS
benzofurans
ring-closing metathesis
GENERAL-SYNTHESIS
HETEROCYCLES
SELECTIVE ISOMERIZATION
FUROCOUMARINS
DERIVATIVES
OLEFIN
CYCLIZATION
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Summary:Twelve substituted benzofurans were synthesized from their corresponding substituted 1-allyl-2-allyloxybenzenes using ruthenium-mediated C- and O-allyl isomerization followed by ring-closing metathesis. Twelve substituted benzofurans were synthesized from their corresponding substituted 1-allyl-2-allyloxybenzenes using ruthenium-mediated C- and O-allyl isomerization followed by ring-closing metathesis.
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2005.05.090