Associations of SUCNR1, GRK4, CAMK1D gene polymorphisms and the susceptibility of type 2 diabetes mellitus and essential hypertension in a northern Chinese Han population

• Published in: Journal of diabetes and its complications Vol. 35; no. 1; p. 107752
• Main Authors: Du, Bingxin, Jia, Xinhui, Tian, Wenqi, Yan, Xueqin, Wang, Ningning, Cai, Defu, Li, Xueyan, Zhang, Hao, Jin, Ming, Wu, Nan, Qiu, Changchun, Zhang, Qi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier Limited
• Subjects: Antihypertensives; Asians - genetics; Blood pressure; Calcium-Calmodulin-Dependent Protein Kinase Type 1; CAMK1D; Case-Control Studies; China - epidemiology; Chronic illnesses; Deoxyribonucleic acid; Design; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetic neuropathy; DNA; Essential Hypertension; G-Protein-Coupled Receptor Kinase 4; Gene polymorphism; Genetic Predisposition to Disease; Genetic testing; Genotype; Glucose; GRK4; Hospitals; Humans; Hypertension; Kinases; Pathogenesis; Polymorphism, Single Nucleotide; Proteins; Receptors, G-Protein-Coupled; Software; SUCNR1; China; United States > US; Hypertension; SUCNR1; CAMK1D; GRK4; Gene polymorphism; Diabetes mellitus
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2020.107752

Diabetes mellitus and hypertension are both complex diseases that are caused by interactions among multiple genetic and physiological factors. To investigate the association of common single-nucleotide polymorphisms (SNPs) of SUCNR1, GRK4 and CAMK1D genes with the susceptibility of the two diseases in a northern Chinese Han population. 36 SNPs were genotyped in 2304 clinical patients (1152 type 2 diabetes mellitus, 1152 essential hypertension) and 1152 health controls by Sequenom Mass-ARRAY RS1000. In this study, we found that BMI, blood press, pulse pressure, FBG, total cholesterol and triglycerides were associated with an increased risk of type 2 diabetes mellitus (T2DM) and essential hypertension (EH). Three SNPs (SUCNR1: rs73168929; GRK4: rs1557213; CAMK1D: rs17151584) significantly associated with the susceptibility of T2DM and EH at the same time. Also, the susceptibility genotypes of 3 SNPs were significantly correlated with liver and renal function parameters. To the best of our knowledge, the present study is the first to report that three SNPs (SUCNR1: rs73168929; GRK4: rs1557213; CAMK1D: rs17151584) contributed to the risk of T2DM and EH in a northern Chinese Han population. These results provide a favourable evidence for better understand of the underlying common mechanism of these two diseases. •SUCNR1, GRK4 and CAMK1D polymorphisms might be associated with the susceptibility of T2DM and EH in Chinese population.•The 3 SNPs (rs73168929, rs1557213 and rs17151584) in the 3 genes might increase the risk of T2DM and EH at the same time.•G allele of rs1557213, rs17151584 and A allele of rs73168929 were associated with liver and renal function parameters.