Gastrointestinal immunity in health and disease

The gastrointestinal lymphoid tissue (GALT) is under constant antigenic challenge from bacteria and food and must be able to distinguish between benign and pathogenic organisms. Recent advances in understanding the organization and function of GALT reveal how it is able to direct appropriate immune...

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Bibliographic Details
Published inThe Veterinary clinics of North America. Small animal practice Vol. 29; no. 2; p. 471
Main Authors Elwood, C M, Garden, O A
Format Journal Article
LanguageEnglish
Published United States 01.03.1999
Subjects
Animals
Digestive System - immunology
Dog Diseases - immunology
Dogs - immunology
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - veterinary
Lymphoid Tissue - immunology
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Summary:The gastrointestinal lymphoid tissue (GALT) is under constant antigenic challenge from bacteria and food and must be able to distinguish between benign and pathogenic organisms. Recent advances in understanding the organization and function of GALT reveal how it is able to direct appropriate immune responses according to the nature of the antigen and how inappropriate immune responses can lead to local and systemic immunopathology and/or infection. The interaction of the normal bowel flora and GALT is critical to normal local and systemic immune function and plays a major role in the pathogenesis of some immune-related diseases. This review draws upon information from veterinary, human, and laboratory animal studies to provide an update of mechanisms and consequences of function and dysfunction in the gastrointestinal immune system.
ISSN:0195-5616
DOI:10.1016/S0195-5616(99)50031-4