A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation

A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO − with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing drug-induced hepatotoxicity and its re...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 95; pp. 1437 - 1431
Main Authors Jiang, Wen-Li, Li, Yongfei, Wang, Wen-Xin, Zhao, Yi-Ting, Fei, Junjie, Li, Chun-Yan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 26.11.2019
Royal Society of Chemistry
Subjects
Acetaminophen - administration & dosage
Acetaminophen - pharmacology
Animals
Cell Line, Tumor
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - pathology
Chemistry
Chemistry, Multidisciplinary
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - analysis
Fluorescent Dyes - chemistry
Fluorescent indicators
Hepatocytes - drug effects
Humans
Infrared Rays
Mice
Mice, Inbred BALB C
Molecular Structure
Optical Imaging
Peroxynitrous Acid - analysis
Physical Sciences
Remediation
Science & Technology
Selectivity
ACETAMINOPHEN
INFLAMMATION
MITOCHONDRIA
PARACETAMOL
ENDOGENOUS PEROXYNITRITE
MECHANISMS
INDUCED LIVER-INJURY
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Summary:A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO − with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing drug-induced hepatotoxicity and its remediation by using hepatoprotective medicines in living cells and mice. A novel hepatocyte-targeting near-infrared ratiometric fluorescent probe named Gal-NIR is developed for detecting ONOO − . The probe can target the hepatocyte and assess drug-induced liver injury and its remediation in living cells and mice.
Bibliography:10.1039/c9cc07017f
Electronic supplementary information (ESI) available: Experimental section, synthesis of probes, additional spectral data, response mechanism and supplemental biological assay. See DOI
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07017f