Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in the Netherlands

In this study, a new method was developed for the impurity profiling of illicit MDMA tablets. The extraction efficiency, linearity, repeatability and reproducibility of the method were evaluated. Eighty two MDMA tablets coming from presumed unrelated large seizures in 2004 (n >500 tablets) were a...

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Bibliographic Details
Published inScience & justice Vol. 46; no. 3; pp. 135 - 152
Main Authors van Deursen, M.M., Lock, E.R.A., Poortman-van der Meer, A.J.
Format Journal Article
LanguageEnglish
Published England Elsevier Ireland Ltd 01.07.2006
Subjects
comparison
Filtration - methods
gas chromatography mass spectrometry
Gas Chromatography-Mass Spectrometry - methods
Hallucinogens - chemistry
Humans
Hydrogen-Ion Concentration
MDMA
N-Methyl-3,4-methylenedioxyamphetamine - chemistry
Netherlands
profiling
Reproducibility of Results
Solvents - chemistry
Street Drugs - chemistry
Tablets
Netherlands
comparison
profiling
MDMA
gas chromatography mass spectrometry
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Summary:In this study, a new method was developed for the impurity profiling of illicit MDMA tablets. The extraction efficiency, linearity, repeatability and reproducibility of the method were evaluated. Eighty two MDMA tablets coming from presumed unrelated large seizures in 2004 (n >500 tablets) were analyzed by gas chromatography mass spectrometry (GC-MS) in order to assess the discrimination power of the method. The latter was found to be practical, robust, relatively easy to perform, highly discriminative and yielding good chromatography. In addition, some new impurities were detected and identified. Their chemical structures and mass spectra are reported.
Bibliography:ObjectType-Article-1
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ISSN:1355-0306
1876-4452
DOI:10.1016/S1355-0306(06)71588-X