Anti-obesity effects of Asian dayflower, Commelina communis, in mice with high-fat diet-induced obesity and in 3T3-L1 cells

•Asian dayflower, Commelina communis tea (CCT), decreased the body weight gain in mice.•CCT lowered the serum glucose and triglyceride levels.•CCT slightly improved insulin sensitivity.•Glucoluteolin, a major flavonoid of C. communis, reduced the intracellular triglyceride level.•Glucoluteolin repre...

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Bibliographic Details
Published inJournal of functional foods Vol. 22; pp. 490 - 503
Main Authors Nagai, Shiori, Wakai, Eri, Shibano, Makio, Fujimori, Ko
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.04.2016
Elsevier
Subjects
Anti-obesity
Asian dayflower
Commelina communis
Glucoluteolin
GLUT4
Tea
C/EBP
2-NBDG
sWAT
aP2
TNFα
MCP-1
ATGL
HFD
ITT
LPL
WAT
LFD
DMEM
PPAR
NEFA
qPCR
UHPLC
HSL
Commelina communis
ACC
vWAT
TBP
Anti-obesity
GLUT
MS
IL-6
Asian dayflower
Tea
MGL
CCT
SCD
Glucoluteolin
FAS
GLUT4
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Summary:•Asian dayflower, Commelina communis tea (CCT), decreased the body weight gain in mice.•CCT lowered the serum glucose and triglyceride levels.•CCT slightly improved insulin sensitivity.•Glucoluteolin, a major flavonoid of C. communis, reduced the intracellular triglyceride level.•Glucoluteolin repressed the expression of the GLUT4 and glucose uptake in 3T3-L1 cells. Asian dayflower, Commelina communis tea (CCT), decreased the body weight gain and reduced the mass of visceral and subcutaneous adipose tissue in the high-fat diet (HFD)-fed mice. The serum glucose and triacylglycerol levels were lowered in CCT-administered HFD-fed mice. Moreover, CCT slightly improved their insulin sensitivity. To elucidate the molecular mechanism of anti-adipogenic effect of C. communis, we focused on the flavonoids that have various physiological functions. The major flavonoids from C. communis were purified by HPLC, and their structures determined by NMR and mass spectrometry. Glucoluteolin (luteolin-7-O-glucoside), a flavonoid of C. communis, reduced the intracellular triacylglycerol level in 3T3-L1 cells. The transcription level of glucose transporter 4 (GLUT4) and glucose uptake were decreased by glucoluteolin. These results indicate that CCT reduced the body weight gain and slightly improved the insulin sensitivity in HFD-fed mice. Glucoluteolin repressed the accumulation of intracellular lipids by suppressing GLUT4-mediated glucose uptake into adipocytes.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2016.02.012