SYNE1‐QK1 SNPs, G × G and G × E interactions on the risk of hyperlipidaemia

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 10; pp. 5772 - 5785
• Main Authors: Zheng, Peng‐Fei, Yin, Rui‐Xing, Liu, Chun‐Xiao, Deng, Guo‐Xiong, Guan, Yao‐Zong, Wei, Bi‐Liu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; Alleles; Blood pressure; Cardiovascular disease; Case-Control Studies; Cholesterol; Cytoskeletal Proteins - genetics; Deoxyribonucleic acid; DNA; Dyslipidemia; environmental factor; Environmental factors; Epistasis, Genetic; Experiments; Female; Gene-Environment Interaction; Genes; Genetic Association Studies; Genetic disorders; Genetic Predisposition to Disease; Genetic testing; Genomes; haplotype; Haplotypes; Haplotypes - genetics; Humans; Hypercholesterolemia - genetics; hyperlipidaemia; Hyperlipidemia; Hyperlipidemias - blood; Hyperlipidemias - genetics; Hypertriglyceridemia - genetics; interaction; KH domain containing RNA binding gene; Life Style; Linkage analysis; Linkage disequilibrium; Linkage Disequilibrium - genetics; Lipids; Lipids - blood; Logistic Models; Male; Metabolism; Middle Aged; Minority & ethnic groups; Morbidity; Multifactor Dimensionality Reduction; Mutation - genetics; Nerve Tissue Proteins - genetics; Original; Polymorphism, Single Nucleotide - genetics; Population; Proteins; Ribonucleic acid; Risk Factors; RNA; RNA-Binding Proteins - genetics; Single-nucleotide polymorphism; Smoking; Spectrin; spectrin repeat containing nuclear envelope protein 1; Viral envelope proteins; Young Adult; China; environmental factor; haplotype; single nucleotide polymorphism; interaction; KH domain containing RNA binding gene; hyperlipidaemia; spectrin repeat containing nuclear envelope protein 1

This study aimed to assess the relationship of 3 spectrin repeat containing nuclear envelope protein 1 (SYNE1) and 4 KH domain containing RNA binding (QK1) single nucleotide polymorphisms (SNPs), their haplotypes, gene‐gene (G × G), gene‐environment (G × E) interactions and hypercholesterolaemia (HC...