SYNE1‐QK1 SNPs, G × G and G × E interactions on the risk of hyperlipidaemia

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 10; pp. 5772 - 5785
• Main Authors: Zheng, Peng‐Fei, Yin, Rui‐Xing, Liu, Chun‐Xiao, Deng, Guo‐Xiong, Guan, Yao‐Zong, Wei, Bi‐Liu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol; Alleles; Blood pressure; Cardiovascular disease; Case-Control Studies; Cholesterol; Cytoskeletal Proteins - genetics; Deoxyribonucleic acid; DNA; Dyslipidemia; environmental factor; Environmental factors; Epistasis, Genetic; Experiments; Female; Gene-Environment Interaction; Genes; Genetic Association Studies; Genetic disorders; Genetic Predisposition to Disease; Genetic testing; Genomes; haplotype; Haplotypes; Haplotypes - genetics; Humans; Hypercholesterolemia - genetics; hyperlipidaemia; Hyperlipidemia; Hyperlipidemias - blood; Hyperlipidemias - genetics; Hypertriglyceridemia - genetics; interaction; KH domain containing RNA binding gene; Life Style; Linkage analysis; Linkage disequilibrium; Linkage Disequilibrium - genetics; Lipids; Lipids - blood; Logistic Models; Male; Metabolism; Middle Aged; Minority & ethnic groups; Morbidity; Multifactor Dimensionality Reduction; Mutation - genetics; Nerve Tissue Proteins - genetics; Original; Polymorphism, Single Nucleotide - genetics; Population; Proteins; Ribonucleic acid; Risk Factors; RNA; RNA-Binding Proteins - genetics; Single-nucleotide polymorphism; Smoking; Spectrin; spectrin repeat containing nuclear envelope protein 1; Viral envelope proteins; Young Adult; China; environmental factor; haplotype; single nucleotide polymorphism; interaction; KH domain containing RNA binding gene; hyperlipidaemia; spectrin repeat containing nuclear envelope protein 1
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/jcmm.15239

This study aimed to assess the relationship of 3 spectrin repeat containing nuclear envelope protein 1 (SYNE1) and 4 KH domain containing RNA binding (QK1) single nucleotide polymorphisms (SNPs), their haplotypes, gene‐gene (G × G), gene‐environment (G × E) interactions and hypercholesterolaemia (HCH) and hypertriglyceridaemia (HTG) in the Chinese Maonan minority. The genetic make‐up of the SYNE1‐QK1 SNPs in 1932 unrelated subjects (normal, 641; HCH, 649; and HTG, 642) was obtained by next‐generation sequencing technologies. The genotypic frequencies of following SNPs were suggestively distinctive between the control and HCH groups (rs2623963, rs7745725, rs9459317, rs16897566), or between the control and HTG groups (rs2623963, rs1358317, rs7745725, rs1923608, rs16897566 SNPs; P < .05, respectively). Multiple‐locus linkage disequilibrium analysis indicated that the identified SNPs were not inherited independently. Several haplotypes and gene‐gene interaction haplotypes among the detected SNPs may be related with an increased morbidity of HCH (C‐G‐A, C‐G‐G and C‐G‐G‐T‐C‐A‐T) and HTG (C‐G‐G, G‐T‐G‐C, C‐G‐G‐G‐T‐G‐C and C‐G‐G‐T‐C‐A‐T), whereas others may be related with an decreased risk of HCH (G‐A‐A, G‐C‐A‐T, C‐A‐A‐T‐C‐A‐T and G‐A‐A‐G‐C‐A‐T) and HTG (G‐A‐A, G‐C‐A‐T, C‐A‐A‐T‐C‐A‐T and G‐A‐A‐G‐C‐A‐T). The association evaluation based on haplotypes and gene‐gene interactions could improve the power of detecting the risk of dyslipidaemia than anyone of SNP alone. There was significant three‐locus model involving SNP‐SNP, haplotype‐haplotype/environment and G × G interactions (P < .05‐0.001) that were detected by GMDR in HCH and HTG groups. Different interactions between genetic and environmental factors would produce different redundancy or synergy effects on the morbidity of HCH and/or HTG.