Catalytic Hydration of Pyridinecarbonitriles in the Presence of [Cu(en)2]Cl2·2H2O and CuCl2·2H2O

Spectrophotometric studies on the catalytic hydration of 2-pyridinecarbonitrile derivatives in the presence of [Cu(en)2]Cl2·2H2O and CuCl2·2H2O under nearly neutral conditions revealed that the products are their amides. In some cases, the yields were calculated from the weight of amides obtained. T...

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Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 47; no. 8; pp. 1948 - 1950
Main Authors Watanabe, Ken-ichi, Murayama, Kiyoshi
Format Journal Article
LanguageEnglish
Published Tokyo The Chemical Society of Japan 01.08.1974
Chemical Society of Japan
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Summary:Spectrophotometric studies on the catalytic hydration of 2-pyridinecarbonitrile derivatives in the presence of [Cu(en)2]Cl2·2H2O and CuCl2·2H2O under nearly neutral conditions revealed that the products are their amides. In some cases, the yields were calculated from the weight of amides obtained. The hydration of the nitrile group was influenced by electronic and steric effects. Selective hydration of the nitrile group in α-position was observed in the case of dinitrile. The selectivity was applied to hydrolysis of nitriles to carboxylic acids.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.47.1948