Ruthenium-Catalyzed Enantioselective Reduction of Electron-Rich Aryl Alkyl Ketones

Presented here is the investigation of the transfer hydrogenation of electron‐rich aryl alkyl ketones using ruthenium complexes of dipeptide‐like ligands and 2‐propanol as hydride source. The reduction proceeded with excellent selectivity (up to>99 % ee) and in moderate to high yields (up to 90 %...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 348; no. 10-11; pp. 1277 - 1282
Main Authors Wettergren, Jenny, Bøgevig, Anders, Portier, Maud, Adolfsson, Hans
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.07.2006
WILEY‐VCH Verlag
Subjects
asymmetric catalysis
hydrogen transfer
ketones
reduction
ruthenium
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Summary:Presented here is the investigation of the transfer hydrogenation of electron‐rich aryl alkyl ketones using ruthenium complexes of dipeptide‐like ligands and 2‐propanol as hydride source. The reduction proceeded with excellent selectivity (up to>99 % ee) and in moderate to high yields (up to 90 %).
Bibliography:ark:/67375/WNG-6NSJKV7F-4
istex:4EF63AE2DE40F46D766ADCE5C8E204D23D595788
ArticleID:ADSC200606067
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200606067