Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy

• Published in: Journal of oncology Vol. 2022; pp. 8901326 - 13
• Main Authors: Aktar, Nasrin, Yueting, Chen, Abbas, Muhammad, Zafar, Hajra, Paiva-Santos, Ana Cláudia, Zhang, Qin, Chen, Tingting, Ahmed, Moudud, Raza, Faisal, Zhou, Xiaohui
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 2022; Hindawi Limited
• Subjects: Antibodies; Antigens; Biomarkers; Cancer therapies; Cytotoxicity; Immune system; Immunology; Immunotherapy; Lymphocytes; Medical research; Melanoma; Pathogenesis; Researchers; Response rates; Review; T cell receptors; Tumors
• ISSN: 1687-8450; 1687-8450
• DOI: 10.1155/2022/8901326

Tumor immune escape has emerged as the most significant barrier to cancer therapy. A thorough understanding of tumor immune escape therapy mechanisms is critical for further improving clinical treatment strategies. Currently, research indicates that combining several immunotherapies can boost antitumor efficacy and encourage T cells to play a more active part in the immune assault. To generate a more substantial therapeutic impact, it can establish an ideal tumor microenvironment (TME), encourage T cells to play a role, prevent T cell immune function reversal, and minimize tumor immune tolerance. In this review, we will examine the mechanisms of tumor immune escape and the limits of tumor immune escape therapy, focusing on the current development of immunotherapy based on tumor immune escape mechanisms. Individualized tumor treatment is becoming increasingly apparent as future treatment strategies. In addition, we forecast the future research direction of cancer and the clinical approach for cancer immunotherapy. It will serve as a better reference for researchers working in cancer therapy research.