Taxanes-induced cutaneous eruption: another histopathologic mimicker of malignancy
Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only establ...
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Published in | Journal of the European Academy of Dermatology and Venereology Vol. 30; no. 4; pp. 638 - 644 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.04.2016
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Subjects | |
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Abstract | Background
Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation.
Objectives
We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically.
Methods
Cutaneous biopsies were obtained in each patient.
Results
Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case.
Discussion
These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported.
Conclusion
Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. |
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AbstractList | BACKGROUNDPaclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation.OBJECTIVESWe report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically.METHODSCutaneous biopsies were obtained in each patient.RESULTSAtypical starburst-like or ring-like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case.DISCUSSIONThese findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under-reported.CONCLUSIONDermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. Objectives We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Methods Cutaneous biopsies were obtained in each patient. Results Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. Discussion These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported. Conclusion Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Cutaneous biopsies were obtained in each patient. Atypical starburst-like or ring-like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under-reported. Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. Abstract Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. Objectives We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Methods Cutaneous biopsies were obtained in each patient. Results Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. Discussion These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported. Conclusion Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. |
Author | Llamas-Velasco, M. Prieto-Torres, L. de Asis, S. Cerroni, L. del Puerto, C. Loredo, A. Requena, L. Carmo, M. Haro, R. Fried, I. Machan, S. Kempf, W. |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26558745$$D View this record in MEDLINE/PubMed |
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Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen... Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These... Abstract Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen... BACKGROUNDPaclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically.... |
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SubjectTerms | Bridged-Ring Compounds - adverse effects Diagnosis, Differential Exanthema - chemically induced Female Humans Male Middle Aged Skin - drug effects Skin - pathology Skin Neoplasms - diagnosis Taxoids - adverse effects |
Title | Taxanes-induced cutaneous eruption: another histopathologic mimicker of malignancy |
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