Taxanes-induced cutaneous eruption: another histopathologic mimicker of malignancy

Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only establ...

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Published inJournal of the European Academy of Dermatology and Venereology Vol. 30; no. 4; pp. 638 - 644
Main Authors Prieto-Torres, L., Llamas-Velasco, M., Machan, S., Haro, R., de Asis, S., Carmo, M., Loredo, A., del Puerto, C., Fried, I., Kempf, W., Cerroni, L., Requena, L.
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.04.2016
Subjects
Bridged-Ring Compounds - adverse effects
Diagnosis, Differential
Exanthema - chemically induced
Female
Humans
Male
Middle Aged
Skin - drug effects
Skin - pathology
Skin Neoplasms - diagnosis
Taxoids - adverse effects
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Abstract Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. Objectives We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Methods Cutaneous biopsies were obtained in each patient. Results Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. Discussion These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported. Conclusion Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes.
AbstractList BACKGROUNDPaclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation.OBJECTIVESWe report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically.METHODSCutaneous biopsies were obtained in each patient.RESULTSAtypical starburst-like or ring-like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case.DISCUSSIONThese findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under-reported.CONCLUSIONDermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes.
Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. Objectives We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Methods Cutaneous biopsies were obtained in each patient. Results Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. Discussion These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported. Conclusion Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes.
Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Cutaneous biopsies were obtained in each patient. Atypical starburst-like or ring-like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under-reported. Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes.
Abstract Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation. Objectives We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically. Methods Cutaneous biopsies were obtained in each patient. Results Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case. Discussion These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported. Conclusion Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes.
Author Llamas-Velasco, M.
Prieto-Torres, L.
de Asis, S.
Cerroni, L.
del Puerto, C.
Loredo, A.
Requena, L.
Carmo, M.
Haro, R.
Fried, I.
Machan, S.
Kempf, W.
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  surname: Llamas-Velasco
  fullname: Llamas-Velasco, M.
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  givenname: A.
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  givenname: C.
  surname: del Puerto
  fullname: del Puerto, C.
  organization: Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
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  givenname: I.
  surname: Fried
  fullname: Fried, I.
  organization: Dermatopathology Research Unit, Medical University of Graz, Graz, Austria
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  organization: Dermatopathology Research Unit, Medical University of Graz, Graz, Austria
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  givenname: L.
  surname: Requena
  fullname: Requena, L.
  email: lrequena@fjd.es
  organization: Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain
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2009; 23
1989; 63
1987; 14
2012; 81
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2013; 20
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1977; 61
1946; 104
1995; 332
2008; 101
2007; 34
2011; 5
2001; 25
2007; 36
2014; 20
2013; 19
2004; 31
2003; 207
2000; 19
2004; 95
2005; 141
2002; 29
2013; 79
1947; 56
1984; 6
2004; 150
1997; 17
2003; 48
2011; 65
2009; 8
2000; 142
2012; 28
2014; 8
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Snippet Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen...
Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These...
Abstract Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen...
BACKGROUNDPaclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically....
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StartPage 638
SubjectTerms Bridged-Ring Compounds - adverse effects
Diagnosis, Differential
Exanthema - chemically induced
Female
Humans
Male
Middle Aged
Skin - drug effects
Skin - pathology
Skin Neoplasms - diagnosis
Taxoids - adverse effects
Title Taxanes-induced cutaneous eruption: another histopathologic mimicker of malignancy
URI https://api.istex.fr/ark:/67375/WNG-63Z9FMSG-J/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjdv.13475
https://www.ncbi.nlm.nih.gov/pubmed/26558745
https://search.proquest.com/docview/1777983456
Volume 30
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