Taxanes-induced cutaneous eruption: another histopathologic mimicker of malignancy
Background Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only establ...
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Published in | Journal of the European Academy of Dermatology and Venereology Vol. 30; no. 4; pp. 638 - 644 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.04.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Paclitaxel and docetaxel are antineoplastic drugs that bind the microtubules, producing the arrest of mitoses, which may be seen histopathologically. These histopathologic changes may simulate an intraepidermal keratinocytic malignant neoplasm, and an accurate diagnosis may be only established by clinicopathological correlation.
Objectives
We report six cases of cutaneous eruptions by taxanes in which a striking cytotoxic effect was evident histopathologically.
Methods
Cutaneous biopsies were obtained in each patient.
Results
Atypical starburst‐like or ring‐like mitoses and dyskeratosis on basal and suprabasal layers of the epidermis. Areas of squamous syringometaplasia were also seen in one case.
Discussion
These findings were interpreted as expression of mitotic arrest due to taxanes. Similar changes have been described in association with other chemotherapeutic drugs such as vincristine, podophyllin and its derivative etoposide; colchicine, busulfan and maytansine, but cases like ours due to taxanes are exceptional or under‐reported.
Conclusion
Dermatopathologists should be aware of these effects in order to interpret carefully cutaneous biopsy specimens of patients receiving taxanes. |
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Bibliography: | ark:/67375/WNG-63Z9FMSG-J ArticleID:JDV13475 istex:0DC6C045454C4E731E03528CC3CE6926647888D6 Funding sources None. Conflicts of Interest The authors have no relevant financial relationships. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0926-9959 1468-3083 |
DOI: | 10.1111/jdv.13475 |