Construction of Pyroptosis-Related Prognostic and Immune Infiltration Signature in Bladder Cancer

Pyroptosis is a kind of programmed cell death related to inflammation, which is closely related to cancer. The goal of this study is to establish and verify pyroptosis-related gene signature to predict the prognosis of patients with bladder cancer (BLCA) and explore its relationship with immunity. S...

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Published inDisease markers Vol. 2022; pp. 6429993 - 22
Main Authors Du, Xiaoyi, Zhao, Xin, Tang, Yu, Tang, Wei
Format Journal Article
LanguageEnglish
Published United States Hindawi 2022
Hindawi Limited
Subjects
Apoptosis
Bladder
Bladder cancer
Cancer
Cell death
Clustering
Copy number
DNA Copy Number Variations
Gene expression
Genes
Genomes
Genomics
Humans
Immune system
Immunotherapy
Infiltration
Medical prognosis
Mutation
Pathogenesis
Prognosis
Pyroptosis
Regression analysis
Risk groups
Survival
Urinary Bladder Neoplasms - genetics
United States > US
China
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Summary:Pyroptosis is a kind of programmed cell death related to inflammation, which is closely related to cancer. The goal of this study is to establish and verify pyroptosis-related gene signature to predict the prognosis of patients with bladder cancer (BLCA) and explore its relationship with immunity. Somatic mutation, copy number variation, correlation, and expression of 33 pyroptosis-related genes were evaluated based on The Cancer Genome Atlas (TCGA) database. BLCA cases were divided into two clusters by consistent clustering and found that pyroptosis-related genes were related to the overall survival (OS) of BLCA. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to construct the signature (including 7 pyroptosis-realated genes). Survival analysis curve and receiver operating characteristic curve (ROC) showed that this signature could predict the prognosis of BLCA patients. Univariate and multivariate Cox regression analysis showed the independent prognostic value of this model. Immune infiltration analysis showed that the six types of immune cells have significantly different infiltrations. The effect of immunotherapy is better in the low-risk group. In summary, our effort indicated the potential role of pyroptosis-related genes in BLCA and provided new perspectives on the prognosis of BLCA and new ideas for immunotherapy.
Bibliography:ObjectType-Article-1
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Academic Editor: Elisa Belluzzi
ISSN:0278-0240
1875-8630
DOI:10.1155/2022/6429993