Clinical presentations of patients from different age cohorts with biliary tract stone diseases

• Published in: Journal of gastroenterology and hepatology Vol. 29; no. 8; pp. 1614 - 1619
• Main Authors: Hu, Kuang-Chun, Wang, Horng-Yuan, Chang, Wen-Hsiung, Chu, Cheng-Hsin, Lin, Shee-Chan, Liu, Chun-Jen, Wu, Ming-Shiang, Shih, Shou-Chuan
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.08.2014
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; aging; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Biomarkers - blood; Choledocholithiasis - diagnosis; Choledocholithiasis - diagnostic imaging; Choledocholithiasis - epidemiology; Cohort Studies; common bile duct stone; endoscopic retrograde cholangiopancreatography; Female; Humans; Incidence; liver function test; Liver Function Tests; Male; Sensitivity and Specificity; transabdominal ultrasound scan; Ultrasonography; Young Adult; endoscopic retrograde cholangiopancreatography; transabdominal ultrasound scan; aging; liver function test; common bile duct stone
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.12581

Background and Aim The role of clinical symptoms, transabdominal ultrasound scan (USS), and liver function tests (LFTs) in evaluating common bile duct (CBD) stones in patients suspected to have pancreatobiliary disease has been studied. However, it is unclear whether these predictive models are useful in different age cohorts. The aim of this study is to investigate the clinical presentations from different age cohorts with and without CBD stones. Methods Four hundred and forty‐three patients with pancreatobiliary diseases were divided into cohorts according to decades as follows: young (Y, 18–64 years old, n = 143), young‐old (YO, 65–74 years old, n = 168), old‐old (OO, 75–84 years old, n = 97), and very old (VO, ≥ 85 years old, n = 35). The clinical symptoms, LFTs, and USS findings were demonstrated and compared among patients. Results Y‐ and YO‐group patients were more likely to develop symptoms such as biliary colic in the presence of CBD stones. The proportion of abnormal serum aspartate aminotransferase and alanine aminotransferase were significantly greater in Y‐, YO‐, and OO‐group patients with than in those without CBD stones. Sensitivity of USS for CBD stones in Y: 0.15; YO: 0.45; OO: 0.57; and VO: 0.68. Accuracy of USS for detected CBD stone in Y: 48%; YO: 62.5%; OO: 70.1%; and VO: 71.4%. Conclusion Combined evaluation of clinical symptoms, biochemical and USS findings may help predict the presence of CBD stones. In Y, YO, and OO patients with CBD stones, the incidences of abnormal LFTs were higher. The sensitivity and accuracy of USS in detecting CBD stones were increased according to age.