Familial Papular Epidermal Nevus with "Skyline" Basal Cell Layer

Papular epidermal nevus with “skyline” basal cell layer (PENS), a novel keratinocytic nevus, has recently been described as a mosaic condition with varying presentations. We herein describe typical PENS lesions, which usually occur sporadically, affecting two members of the same family. The concept...

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Bibliographic Details
Published inPediatric dermatology Vol. 31; no. 1; pp. e33 - e35
Main Authors Brena, Michela, Besagni, Francesca, Boneschi, Vinicio, Tadini, Gianluca
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.01.2014
Subjects
Biopsy
Epidermis - pathology
Family
Female
Humans
Infant
Keratinocytes - pathology
Male
Nevus
Nevus, Pigmented - genetics
Nevus, Pigmented - pathology
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Young Adult
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Summary:Papular epidermal nevus with “skyline” basal cell layer (PENS), a novel keratinocytic nevus, has recently been described as a mosaic condition with varying presentations. We herein describe typical PENS lesions, which usually occur sporadically, affecting two members of the same family. The concept of paradominant inheritance is proposed to explain the paradox of occasional transmission of normally sporadically occurring traits.
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ISSN:0736-8046
1525-1470
DOI:10.1111/pde.12251