Predictive value of integrin α7 for acute myeloid leukemia risk and its correlation with prognosis in acute myeloid leukemia patients

• Published in: Journal of clinical laboratory analysis Vol. 34; no. 4; pp. e23151 - n/a
• Main Authors: Zeng, Mingyue, Ding, Siruiyun, Zhang, Hui, Huang, Qianqian, Ren, yi, Guo, Pengxiang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2020; John Wiley and Sons Inc
• Subjects: Acute myeloid leukemia; Age; Antigens, CD - genetics; Antigens, CD - metabolism; Biopsy; Bone marrow; Cancer; Case-Control Studies; Cell adhesion & migration; Chemotherapy; Classification; Clinical medicine; complete remission; Cytogenetics; Disease-Free Survival; event‐free survival; Female; Gene expression; Gene Expression Regulation, Leukemic; Humans; Integrin alpha Chains - genetics; Integrin alpha Chains - metabolism; integrin α7; Leukemia; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Male; Medical prognosis; Middle Aged; Mutation; Myeloid leukemia; overall survival; Polymerase chain reaction; Predictive Value of Tests; Prognosis; Protein expression; Proteins; Remission; Remission Induction; Risk Assessment; Risk Factors; RNA, Messenger - genetics; RNA, Messenger - metabolism; Software; Stem cells; Survival; overall survival; integrin α7; event-free survival; acute myeloid leukemia; complete remission
• ISSN: 0887-8013; 1098-2825
• DOI: 10.1002/jcla.23151

Background This study aimed to explore the predictive value of integrin α7 (ITGA7) for acute myeloid leukemia (AML) risk and subsequently investigate its correlation with risk stratification and prognosis in AML patients. Methods Bone marrow samples were obtained from 196 de novo AML patients prior to initiation of treatment and from 50 subjects underwent bone marrow donation or bone marrow biopsy for non‐hematologic malignant disease (as controls). ITGA7 mRNA and protein expressions were detected by real‐time quantitative polymerase chain reaction and Western blot assays, respectively. In AML patients, the risk stratification was assessed, and complete remission (CR), event‐free survival (EFS), and overall survival (OS) were evaluated. Results Both ITGA7 mRNA and protein expressions were increased in AML patients compared with controls, and their expressions were correlated with poorer risk stratification. For prognosis, ITGA7 mRNA expression and protein expression were declined in CR patients compared to non‐CR patients. Meanwhile, both EFS and OS were shorter in ITGA7 mRNA high expression patients compared to ITGA7 mRNA low expression patients, as well as ITGA7 protein high expression patients compared to ITGA7 protein low expression patients. Conclusion Integrin α7 might serve as a potential biomarker for predicting increased AML risk and worse prognosis in AML patients.