Risk of adenomas with high-risk characteristics based on two previous colonoscopy
Background and Aim The recommended intervals between surveillance colonoscopies are based on the most recent examination findings. However, whether the two previous colonoscopies affect second surveillance colonoscopic findings is not established. The aim of this study is to estimate the risk of obt...
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Published in | Journal of gastroenterology and hepatology Vol. 29; no. 12; pp. 1985 - 1990 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Australia
Blackwell Publishing Ltd
01.12.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Background and Aim
The recommended intervals between surveillance colonoscopies are based on the most recent examination findings. However, whether the two previous colonoscopies affect second surveillance colonoscopic findings is not established. The aim of this study is to estimate the risk of obtaining high‐risk findings (HRF) on the next surveillance colonoscopy using the results of two previous colonoscopies, and to estimate the appropriate time interval for the next surveillance colonoscopy.
Methods
Among subjects who underwent screening colonoscopy during January 2002–December 2009, patients who underwent second surveillance colonoscopy before June 2012 were enrolled. “No adenoma” was defined as a hyperplastic polyp or no polyp, “low‐risk findings (LRF)” as one or two small (< 1 cm) tubular adenomas, and “HRF” as advanced adenoma, cancer, or any sized multiple (≥ 3) adenomas.
Results
Among enrolled 852 subjects, 65 (7.6%) had HRF at second surveillance colonoscopy. Multivariate analysis showed that HRF on second surveillance colonoscopy were associated with male and HRF on screening colonoscopy (all, P < 0.01). In subjects with LRF on first surveillance colonoscopy, HRF on the screening colonoscopy significantly affected the detection of HRF on second surveillance colonoscopy (P < 0.01). Patients with HRF on screening colonoscopy and LRF on the first surveillance colonoscopy had no different risk of HRF on second surveillance colonoscopy from those with HRF on first surveillance colonoscopy (P > 0.05).
Conclusions
The HRF on second surveillance are significantly associated with previous two colonoscopic results. In patients with LRF on first surveillance, screening colonoscopic findings should be considered to determine the optimal surveillance interval. |
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Bibliography: | ArticleID:JGH12650 istex:3C7F4217BE889E3AD93A7154E5DBBD81A322335F ark:/67375/WNG-6JX1MN78-N ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0815-9319 1440-1746 |
DOI: | 10.1111/jgh.12650 |