Naloxone blocks the aversive effects of electrical stimulation of the parabrachial complex in a place discrimination task

• Published in: Neurobiology of learning and memory Vol. 136; pp. 21 - 27
• Main Authors: Hurtado, María M, García, Raquel, Puerto, Amadeo
• Format: Journal Article
• Language: English
• Published: United States Elsevier BV 01.12.2016
• Subjects: Animals; Avoidance Learning - drug effects; Avoidance Learning - physiology; Behavior, Animal - drug effects; Behavior, Animal - physiology; Drug therapy; Electric currents; Electric Stimulation; Male; Motivation - drug effects; Motivation - physiology; Naloxone - pharmacology; Narcotic Antagonists - pharmacology; Parabrachial Nucleus - drug effects; Parabrachial Nucleus - physiology; Psychological tests; Rats; Rats, Wistar; Reward; Side effects; Spatial Learning - drug effects; Spatial Learning - physiology; Electrical brain stimulation; Parabrachial complex; Wistar rats; Naloxone; Place preference and aversion learning
• ISSN: 1074-7427; 1095-9564
• DOI: 10.1016/j.nlm.2016.09.011

The parabrachial complex is known to participate in various rewarding and aversive processes, including those related to the learning of taste or place discrimination and the motivational effects of drugs of abuse, such as morphine. This study shows that electrical stimulation of the external lateral parabrachial (LPBe) subnucleus induces consistent place avoidance or place preference in three-compartment rectangular mazes. Administration of naloxone, an opiate antagonist, blocks both motivational effects induced by the intracranial electrical stimulation. Subsequent re-administration of the electrical stimulation was found to recover its aversive but not its rewarding effects after vehicle administration. These results are discussed in relation to different natural and artificial agents involved in the induction of avoidance and preference motivational processes, especially with regard to the opioid system.