Neonatal treatment with resveratrol decreases postural and strength impairments and improves mitochondrial function in the somatosensory cortex rats submitted to cerebral palsy

• Published in: Neurochemistry international Vol. 168; p. 105568
• Main Authors: da Silva Souza, Vanessa, Manhães-de-Castro, Raul, Pereira, Sabrina da Conceição, Calado, Caio Matheus Santos da Silva, Souza de Silveira, Beatriz, Araújo, Eulália Rebeca da Silva, Silva, Severina Cassia de Andrade, Junior, Osmar Henrique dos Santos, Lagranha, Claudia Jacques, da Silva, Luan Kelwyny Thaywã Marques, Toscano, Ana Elisa
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2023
• Subjects: Cerebral palsy; Mitochondrial function; Oxidative stress; Posture; Resveratrol; Cerebral palsy; Oxidative stress; Mitochondrial function; Resveratrol; Posture
• ISSN: 0197-0186; 1872-9754
• DOI: 10.1016/j.neuint.2023.105568

Cerebral palsy is a neurodevelopmental disease characterized by postural, motor, and cognitive disorders, being one of the main causes of physical and intellectual disability in childhood. To minimize functional impairments, the use of resveratrol as a therapeutic strategy is highlighted due to its neuroprotective and antioxidant effects in different regions of the brain. Thus, this study aimed to investigate the effects of neonatal treatment with resveratrol on postural development, motor function, oxidative balance, and mitochondrial biogenesis in the brain of rats submitted to a cerebral palsy model. Neonatal treatment with resveratrol attenuated deficits in somatic growth, postural development, and muscle strength in rats submitted to cerebral palsy. Related to oxidative balance, resveratrol in cerebral palsy decreased the levels of MDA and carbonyls. Related to mitochondrial biogenesis, was observed in animals with cerebral palsy treated with resveratrol, an increase in mRNA levels of TFAM, in association with the increase of citrate synthase activity. The data demonstrated a promising effect of neonatal resveratrol treatment, improving postural and muscle deficits induced by cerebral palsy. These findings were associated with improvements in oxidative balance and mitochondrial biogenesis in the brain of rats submitted to cerebral palsy. •CP model impaired weight gain, somatic growth, physical features maturation, muscle strength, and posture.•RES improved posture and muscle strength in animals submitted to cerebral palsy.•RES decreases oxidative stress markers and improves mitochondrial biogenesis in the somatosensory cortex of animals with CP.