Neuroprotective effect of lycopene against MPTP induced experimental Parkinson’s disease in mice

• Published in: Neuroscience letters Vol. 599; pp. 12 - 19
• Main Authors: Prema, Asokan, Janakiraman, Udaiyappan, Manivasagam, Thamilarasan, Justin Thenmozhi, Arokiasamy
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.07.2015
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Apoptosis; Apoptosis - drug effects; Behavior; Carotenoids - pharmacology; Carotenoids - therapeutic use; Caspase 3 - metabolism; Caspase 8 - metabolism; Caspase 9 - metabolism; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cytochromes c - metabolism; Dopamine - metabolism; Experimental Parkinson’s disease; Hand Strength; Lycopene; Male; Mice, Inbred C57BL; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative stress; Oxidative Stress - drug effects; Parkinson Disease - drug therapy; Parkinson Disease - etiology; Parkinson Disease - physiopathology; Proto-Oncogene Proteins c-bcl-2 - metabolism; Substantia Nigra - drug effects; Substantia Nigra - metabolism; Oxidative stress; Behavior; Experimental Parkinson’s disease; Lycopene; Apoptosis
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2015.05.024

•Lycopene ameliorates MPTP induced behavioral deficts.•Lycopene reverses MPTP mediated neurochemical depletion.•Lycopene attenuates MPTP induced oxidative stress.•Lycopene reduces apoptosis in PD mice. Parkinson’s disease (PD) is the second most common neurodegenerative disorder that mainly affects the movement of the aged populations. Lycopene is a carotenoid with unique pharmacological properties and its efficacy on experimental Hunginton’s disease and brain ischemia has shown intense neuroprotective effects. The present study was aimed to explore the neuroprotective effect of lycopene against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced PD mice. Administration of lycopene (5, 10 and 20mg/kg/day orally) protected MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose dependent manner. It also attenuated MPTP-induced oxidative stress and motor abnormalities seen in PD mice. Our western blot studies showed that treatment with lycopene reversed MPTP induced apoptosis may be due to its antioxidant and antiapoptotic properties. As to conclude, lycopene reverses neurochemical deficts, oxidative stress, apoptosis and physiological abnormalities in PD mice and offer promise strategy in the treatment of this neurodegenerative disease.