Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum

It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-D-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-indu...

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Bibliographic Details
Published inBrain research Vol. 445; no. 1; p. 147
Main Authors Yi, S J, Snell, L D, Johnson, K M
Format Journal Article
LanguageEnglish
Published Netherlands 29.03.1988
Subjects
Animals
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Aspartic Acid - pharmacology
Cerebellum - drug effects
Cerebellum - metabolism
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
In Vitro Techniques
Male
N-Methylaspartate
Norepinephrine - metabolism
Phencyclidine - metabolism
Phencyclidine - pharmacology
Rats
Rats, Inbred Strains
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter - drug effects
Receptors, Neurotransmitter - physiology
Receptors, Phencyclidine
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Summary:It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-D-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.
ISSN:0006-8993
DOI:10.1016/0006-8993(88)91084-0