Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

• Published in: European journal of medicinal chemistry Vol. 210; p. 113092
• Main Authors: Fang, Yuxi, Li, Haonan, Ji, Bao, Cheng, Keguang, Wu, Bo, Li, Zhanlin, Zheng, Chao, Hua, Huiming, Li, Dahong
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 15.01.2021
• Subjects: Alkaloid; Alkaloids - chemical synthesis; Alkaloids - chemistry; Alkaloids - pharmacology; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics, Antineoplastic - chemical synthesis; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Antiprotozoal Agents - chemical synthesis; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Biological Products - chemical synthesis; Biological Products - chemistry; Biological Products - pharmacology; Medicinal chemistry; Molecular Structure; Neoplasms - drug therapy; Renieramycins; Synthetic chemistry; Tetrahydroisoquinolines - chemical synthesis; Tetrahydroisoquinolines - chemistry; Tetrahydroisoquinolines - pharmacology; Renieramycins; Alkaloid; Medicinal chemistry; Synthetic chemistry

Marine natural products are known for their diverse chemical structures and extensive bioactivities. Renieramycins, the member of tetrahydroisoquinoline family of marine natural products, arouse interests because of their strong antitumor activities and similar structures to the first marine antitum...