Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

• Published in: European journal of medicinal chemistry Vol. 210; p. 113092
• Main Authors: Fang, Yuxi, Li, Haonan, Ji, Bao, Cheng, Keguang, Wu, Bo, Li, Zhanlin, Zheng, Chao, Hua, Huiming, Li, Dahong
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 15.01.2021
• Subjects: Alkaloid; Alkaloids - chemical synthesis; Alkaloids - chemistry; Alkaloids - pharmacology; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antibiotics, Antineoplastic - chemical synthesis; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacology; Antiprotozoal Agents - chemical synthesis; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; Biological Products - chemical synthesis; Biological Products - chemistry; Biological Products - pharmacology; Medicinal chemistry; Molecular Structure; Neoplasms - drug therapy; Renieramycins; Synthetic chemistry; Tetrahydroisoquinolines - chemical synthesis; Tetrahydroisoquinolines - chemistry; Tetrahydroisoquinolines - pharmacology; Renieramycins; Alkaloid; Medicinal chemistry; Synthetic chemistry
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2020.113092

Marine natural products are known for their diverse chemical structures and extensive bioactivities. Renieramycins, the member of tetrahydroisoquinoline family of marine natural products, arouse interests because of their strong antitumor activities and similar structures to the first marine antitumor agent ecteinascidin-743, approved by the European Union. According to the literatures, researches on the pharmacological activities of renieramycins mainly focus on their antitumor activities. In addition, by structural modification, derivatives of renieramycins show stronger antiproliferative activity and less accidental necrosis activity on cells. Nevertheless, the difficulties in extraction and separation hinder their further development. Hence, the synthetic chemistry work of renieramycins plays a key role in their further development. In this review, currently reported researches on the synthetic chemistry, pharmacological activities and structural modification of renieramycins are summarized, which will benefit future drug development and innovation. [Display omitted] •The synthetic strategies, structural modification sites and potent derivatives of renieramycins were summarized.•The structures and their features were listed.•Anti-tumor activities and mechanisms were reviewed.