Diverse chemical space of indoleamine-2,3-dioxygenase 1 (Ido1) inhibitors

• Published in: European journal of medicinal chemistry Vol. 211; p. 113071
• Main Authors: Singh, Rahul, Salunke, Deepak B.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 05.02.2021
• Subjects: Biological Products; COVID-19 - drug therapy; Enzyme inhibition; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Humans; IDO1 inhibitor; Immunomodulators; Indoleamine-2,3-dioxygenase; Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors; Kynurenine pathway; Structure-Activity Relationship; Enzyme inhibition; Indoleamine-2,3-dioxygenase; Immunomodulators; IDO1 inhibitor; Kynurenine pathway
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2020.113071

Indoleamine-2,3-dioxygenase 1 (IDO1) catalyses the first and rate limiting step of kynurenine pathway accounting for the major contributor of L-Tryptophan degradation. The Kynurenine metabolites are identified as essential cofactors, antagonists, neurotoxins, immunomodulators, antioxidants as well as carcinogens. The catalytic active site of IDO1 enzyme consists of hydrophobic Pocket-A positioned in the distal heme site and remains connected to a second hydrophobic Pocket-B towards the entrance of the active site. IDO1 enzyme also relates directly to the modulation of the innate and adaptive immune system. Various studies proved that the over expression of IDO1 enzyme play a predominant role in the escape of immunity during cancer progression. Recently, there has been considerable interest in evaluating the potential of IDO1 inhibitors to mobilize the body’s immune system against solid tumours. In the last two decades, enormous attempts to advance new IDO1 inhibitors are on-going both in pharmaceutical industries and in academia which resulted in the discovery of a diverse range of selective and potent IDO1 inhibitors. The IDO1 inhibitors have therapeutic utility in various diseases and in the near future, it may have utility in the treatment of COVID-19. Despite various reviews on IDO1 inhibitors in last five years, none of the reviews provide a complete overview of diverse chemical space including naturally occurring and synthetic IDO1 inhibitors with detailed structure activity relationship studies. The present work provides a complete overview on the IDO1 inhibitors known in the literature so far along with the Structure-Activity Relationship (SAR) in each class of compounds. [Display omitted] •IDO1 inhibitors have therapeutic utility in various diseases.•Enormous attempts resulted in the discovery of a diverse range of selective and potent IDO1 inhibitors.•The review provides a complete overview of a diverse chemical space showing promising IDO1 inhibitory activities.•The inhibitors are classified as “Natural Products” and “Natural Product Inspired” Synthetic IDO1 Inhibitors.•A detailed structure activity relationship studies in each class of compounds in described.