Large Fetal Goiter due to Placental Passage of Maternal Antithyroperoxidase Antibodies

We report a case of fetal goiter in a pregnant woman with Graves-Basedow disease. It was diagnosed in the third trimester by a routine ultrasound, and the cordocentesis verified increased levels of thyroxine (T4) and increased autoantibodies (antithyroperoxidase antibodies) that were also increased...

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Bibliographic Details
Published inFetal diagnosis and therapy Vol. 29; no. 2; pp. 178 - 180
Main Authors Vico, Irene, Molina, Francisca S., Alarcón-Blanco, Pedro, Durán, Santiago, Azumendi, Guillermo
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.01.2011
S. Karger AG
Subjects
Adult
Autoantibodies - blood
Biological and medical sciences
Delivery. Postpartum. Lactation
Endocrinopathies
Female
Fetal Diseases - diagnostic imaging
Fetal Diseases - immunology
General aspects
Goiter - diagnostic imaging
Goiter - immunology
Graves Disease - immunology
Gynecology. Andrology. Obstetrics
Humans
Images in Fetal Medicine
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Placental Circulation
Pregnancy
Thyroid. Thyroid axis (diseases)
Ultrasonography
Fetal goiter
Prenatal diagnosis
Hypothyroidism
Intrauterine treatment
Hyperthyroidism
Endocrinopathy
Antibody
Thyroid diseases
Neonatology
Pregnancy
Medicine
Placenta
Mother
Goiter
Fetus
Fetal therapy
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Summary:We report a case of fetal goiter in a pregnant woman with Graves-Basedow disease. It was diagnosed in the third trimester by a routine ultrasound, and the cordocentesis verified increased levels of thyroxine (T4) and increased autoantibodies (antithyroperoxidase antibodies) that were also increased in maternal blood. Fetal goiter got smaller on the follow-up scans, and the newborn presented hypothyroidism. Current notions on the diagnosis and management of fetal goiter are briefly discussed.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:1015-3837
1421-9964
DOI:10.1159/000321362