Recovery effect of phenylpropanoid glycosides from Magnolia obovata fruit on alloxan-induced pancreatic islet damage in zebrafish (Danio rerio)

• Published in: Carbohydrate research Vol. 416; pp. 70 - 74
• Main Authors: Seo, Kyeong-Hwa, Nam, Youn-Hee, Lee, Dae-Young, Ahn, Eun-Mi, Kang, Tong-Ho, Baek, Nam-In
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 30.10.2015; Elsevier
• Subjects: Alloxan; Alloxan - adverse effects; Animals; Anti-diabetic; Biochemistry & Molecular Biology; Chemistry; Chemistry, Applied; Chemistry, Organic; Cytoprotection - drug effects; Fruit - chemistry; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Islets of Langerhans - cytology; Islets of Langerhans - drug effects; Life Sciences & Biomedicine; Magnolia - chemistry; Magnolia obovata; Obovatoside; Pancreatic islet; Physical Sciences; Propanols - chemistry; Science & Technology; Zebrafish; Alloxan; Zebrafish; Anti-diabetic; Pancreatic islet; Obovatoside; Magnolia obovata; BEHAVIOR; GLUCOSE; EXTRACT
• ISSN: 0008-6215; 1873-426X
• DOI: 10.1016/j.carres.2015.07.010

•Three new phenylpropanoid glycosides were isolated from Magnolia obovata fruit.•Recovery effects on alloxan-induced islet damage in zebrafish were evaluated.•All compounds increased the size of injured pancreatic islets 0.60- to 1.14-fold.•The isolated phenylpropanoids increased the glucose absorption ability in zebrafish. Investigation of phytochemicals from Magnolia obovata fruit led to the isolation of three novel phenylpropanoid glycosides: obovatoside A–C (1–3) and two known phenylpropanoids, syringin (4) and pavonisol (5). The structures of 1–5 were determined by NMR, HRMS, IR and CD spectroscopic analyses. All compounds were evaluated for their effects on recovery from alloxan-induced pancreatic islet damage in zebrafish. All compounds increased the size of the injured pancreatic islet from 0.60- to 1.14-fold. Compounds 1 and 3–5 significantly increased glucose absorption in zebrafish.