Serum sCD163 as a biomarker of adipose tissue inflammation in obstructive sleep apnoea patients: limits and perspectives

Recently, Murphy et al. [1] demonstrated, through a challenging animal, cellular and human translational approach, that intermittent hypoxia induces a pro-inflammatory activation of adipose tissue macrophages (ATMs), promoting insulin resistance. They confirmed that intermittent hypoxia lowers insul...

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Bibliographic Details
Published inThe European respiratory journal Vol. 50; no. 2; p. 1701038
Main Authors Monneret, Denis, Bastard, Jean-Philippe
Format Journal Article
LanguageEnglish
Published England European Respiratory Society Journals Ltd 01.08.2017
European Respiratory Society
Subjects
Adipocytes
Adipose tissue
Apnea
CD163 antigen
Cell activation
Hypoxia
Inflammation
Insulin
Insulin resistance
Life Sciences
Macrophages
Sleep
Sleep apnea
Sleep deprivation
Sleep disorders
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Summary:Recently, Murphy et al. [1] demonstrated, through a challenging animal, cellular and human translational approach, that intermittent hypoxia induces a pro-inflammatory activation of adipose tissue macrophages (ATMs), promoting insulin resistance. They confirmed that intermittent hypoxia lowers insulin-mediated glucose uptake in 3T3-L1 adipocytes, and evidenced the interrelationship between inflammation and insulin resistance in the adipose tissue of mice exposed to intermittent hypoxia. They then measured the concentration of serum soluble CD163 (sCD163), an assumed pro-inflammatory biomarker reflecting macrophage activation, in obstructive sleep apnoea (OSA) patients classified according to their BMI and apnoea/hypopnoea index (AHI). This is the first time serum sCD163 has been evaluated in OSA patients, and its association with AHI is promising. With the aim of enhancing its relevance in further studies, we wish to discuss the following points.
Bibliography:SourceType-Other Sources-1
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ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0903-1936
1399-3003
DOI:10.1183/13993003.01038-2017