Alkylated chitosan-attapulgite composite sponge for rapid hemostasis

This study reported the development of a composite sponge (ACATS) based on alkylated chitosan (AC) and attapulgite (AT) for rapid hemostasis. The well-designed ACATS, with an optimal AC N-alkylation of 5.9 % and an optimal AC/AT mass ratio of 3:1, exhibited a hierarchical porous structure with a fav...

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Bibliographic Details
Published inBiomaterials advances Vol. 153; p. 213569
Main Authors Chen, Xue, Yan, Guoliang, Chen, Ming, Yang, Ping, Xu, Bolin
Format Journal Article
LanguageEnglish
Published Netherlands 01.10.2023
Subjects
Attapulgite
Alkylated chitosan
Composite sponge
Rapid hemostasis
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Summary:This study reported the development of a composite sponge (ACATS) based on alkylated chitosan (AC) and attapulgite (AT) for rapid hemostasis. The well-designed ACATS, with an optimal AC N-alkylation of 5.9 % and an optimal AC/AT mass ratio of 3:1, exhibited a hierarchical porous structure with a favorable biocompatibility. The ACATS can effectively and rapidly stop the uncontrolled bleeding in 235 ± 64 s with a total blood loss of 8.4 ± 4.0 g in comparison with those of Celox as a positive control (602 ± 101 s and 22.3 ± 2.4 g, respectively) using rabbit carotid artery injury model in vivo. ACATS could rapidly interact with blood and its components, including platelets (PLs), red blood cells (RBCs), and coagulation factors, resulting in these blood components rapidly accumulation and the following thrombus formation and coagulation factors activation.
ISSN:2772-9508
DOI:10.1016/j.bioadv.2023.213569