A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni

Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination. In this study we demonstrate that...

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Published inVeterinary immunology and immunopathology Vol. 219; p. 109985
Main Authors Bouvet, J., Lemaitre, L., Cariou, C., Scotto, M., Blain, C., Oberli, F., Cupillard, L., Guigal, P.M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2020
Subjects
Copenhageni
Cross protection
Dog
Leptospirosis
Vaccine
Leptospirosis
Copenhageni
Vaccine
Dog
Cross protection
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Summary:Efficacy of the Leptospira components of multivalent vaccine DAPPi-L was previously demonstrated against virulent challenge with three serovars of Leptospira interrogans (Canicola, Icterohaemorrhagiae and Grippotyphosa) carried out 14 days after primary vaccination. In this study we demonstrate that this vaccine provides, two weeks after vaccination, an additional protection (prevention of mortality, clinical signs, renal infection, bacterial excretion, renal carriage and renal lesions) against fatal leptospirosis due to Leptospira interrogans serovar Copenhageni (serovar of major medical importance).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2019.109985