Contemporary theory of enantioseparations in capillary electrophoresis

•Mechanisms of enantioseparations in CE are discussed.•Differences between CE and chromatographic techniques are highlighted.•NMR studies related to enantioseparations in CE are overviewed.•Enantiomer migration order in CE and application of combined chiral selectors is highlighted. The first separa...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 1567; pp. 2 - 25
Main Author Chankvetadze, Bezhan
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 14.09.2018
Subjects
Capillary electrophoresis
Chiral separation mechanisms in CE
Cyclodextrins
Enantioseparations
Theory
Enantioseparations
Chiral separation mechanisms in CE
Cyclodextrins
Capillary electrophoresis
Theory
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Summary:•Mechanisms of enantioseparations in CE are discussed.•Differences between CE and chromatographic techniques are highlighted.•NMR studies related to enantioseparations in CE are overviewed.•Enantiomer migration order in CE and application of combined chiral selectors is highlighted. The first separation of enantiomers in capillary electrophoresis (CE) counts slightly longer than three decades. Fast development of the practice and theory of chiral CE occurred in the past 30 years and today one can consider this technology to have a solid and mature theoretical background. The goal of the present review is not only to summarize the history and contemporary theory of enantioseparations by using CE but also to present the authors personal view where shall we head to with this attractive technology not only from the viewpoint of separation of enantiomers but also for better understanding the mechanisms of non-covalent (enantioselective) interactions in chemistry, biology, medicine and related disciplines.
ISSN:0021-9673
1873-3778
DOI:10.1016/j.chroma.2018.07.041