Laser spectroscopy technique for estimating the efficiency of photosensitisers in biological media

A fast and highly informative method is presented for estimating the photodynamic activity of photosensitisers. The method makes it possible to determine the rate of photodegradation in erythrocyte-containing biological media in nearly in vivo conditions, estimate the degree of irreversible binding...

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Bibliographic Details
Published inQuantum electronics (Woodbury, N.Y.) Vol. 36; no. 6; pp. 562 - 568
Main Authors Ryabova, A V, Stratonnikov, Aleksandr A, Loshchenov, V B
Format Journal Article
LanguageEnglish
Published United States IOP Publishing 30.06.2006
Subjects
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
EFFICIENCY
ELECTROMAGNETIC RADIATION
ELEMENTS
ERYTHROCYTES
IN VIVO
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
LASER RADIATION
LASER SPECTROSCOPY
MATERIALS
NONMETALS
OXYGEN
PHOTOSENSITIVITY
RADIATIONS
SENSITIVITY
SENSORS
SPECTROSCOPY
VISIBLE RADIATION
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Summary:A fast and highly informative method is presented for estimating the photodynamic activity of photosensitisers. The method makes it possible to determine the rate of photodegradation in erythrocyte-containing biological media in nearly in vivo conditions, estimate the degree of irreversible binding of oxygen dissolved in the medium during laser irradiation in the presence of photosensitisers, and determine the nature of degradation of photosensitisers exposed to light (photobleaching). (laser biology)
ISSN:1063-7818
1468-4799
DOI:10.1070/QE2006v036n06ABEH013291