Recent developments in anti-Trichomonas research: An update review

• Published in: European journal of medicinal chemistry Vol. 143; pp. 232 - 243
• Main Authors: Bala, Veenu, Chhonker, Yashpal S.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2018
• Subjects: Antiparasitic Agents - chemistry; Antiparasitic Agents - isolation & purification; Antiparasitic Agents - pharmacology; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Dose-Response Relationship, Drug; Humans; Metronidazole (MTZ); Molecular Structure; MTZ resistant; MTZ susceptible; Parasitic Sensitivity Tests; Sexually transmitted infection (STI); Structure-Activity Relationship; Trichomonas - drug effects; Trichomonas Infections - drug therapy; Trichomonas Infections - parasitology; Trichomonas vaginalis; Trichomoniasis; Trichomonas vaginalis; Sexually transmitted infection (STI); MTZ resistant; Metronidazole (MTZ); Trichomoniasis; MTZ susceptible
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2017.11.029

Trichomonas vaginalis is a major non-viral sexually-transmitted infection resulted into serious obstetrical and gynecological troubles. The increasing resistance to nitroimidazole therapy and recurrence makes it crucial to develop new drugs against trichomoniasis. Over the past few years, a large number of research articles highlighting the synthetic and natural product research to combat Trichomonas vaginalis have been published. Electronic databases were searched to collect all data from the year 2006 through June 2017 for anti-Trichomonas activity potential of synthetic and natural products. This review article put together the synthetic and natural product research to find out an effective metronidazole alternative to cure trichomoniasis. [Display omitted] •Trichomonas vaginalis is a major non-viral sexually-transmitted infection.•Resistance towards metronidazole enhances the requirement of alternate therapy for T. vaginalis.•This report describes synthetic and natural product anti-Trichomonas research in the past decade.