Vitamin E Deficiency and Oxidative Status are Associated with Prediabetes in Apparently Healthy Subjects

• Published in: Archives of medical research Vol. 48; no. 3; pp. 257 - 262
• Main Authors: Rodríguez-Ramírez, Gabriela, Simental-Mendía, Luis E., Carrera-Gracia, Manuela de la A., Quintanar-Escorza, Martha-Angélica
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2017
• Subjects: Adult; Antioxidant capacity; Antioxidants - metabolism; Blood Glucose - analysis; Case-Control Studies; Female; Glucose Intolerance - blood; Humans; Lipid Peroxidation; Lipoperoxidation; Male; Middle Aged; Oxidative status; Oxidative Stress; Prediabetes; Prediabetic State - blood; Prediabetic State - complications; Vitamin E deficiency; Vitamin E Deficiency - blood; Vitamin E Deficiency - complications; Waist Circumference; Antioxidant capacity; Oxidative status; Prediabetes; Lipoperoxidation; Vitamin E deficiency
• ISSN: 0188-4409; 1873-5487
• DOI: 10.1016/j.arcmed.2017.03.018

Previous studies have indicated that vitamin E deficiency and oxidative stress affect the beta cell function. Hence, the aim of this study was to determine the association between vitamin E deficiency and oxidative status with prediabetes in apparently healthy subjects. Apparently healthy men and women aged 18–65 years were enrolled in a case-control study. Individuals with new diagnosis of prediabetes were considered as cases and compared with a control group of individuals with normal glucose tolerance. Smoking, alcohol intake, pregnancy, diabetes, kidney disease, liver disease, cardiovascular disease, malignancy, glucocorticoid treatment and consumption of lipid-lowering drugs, antioxidants and vitamin supplements were exclusion criteria. Vitamin E deficiency was defined by serum levels of α-tocopherol <11.6 μmol/L, oxidative status was assessed by total antioxidant capacity and lipid peroxidation, and prediabetes was considered by the presence of impaired fasting glucose and/or impaired glucose tolerance. A total of 148 subjects were allocated into the case (n = 74) and control (n = 74) groups. The frequency of vitamin E deficiency was higher in the case group (41.8%) compared with the control group (35.1%), p = 0.03. The logistic regression analysis adjusted by age, waist circumference and body mass index, revealed a significant association between vitamin E deficiency (OR 3.23; 95% CI: 1.34–7.79, p = 0.009), lipoperoxidation (OR 2.82; CI 95%: 1.42–5.59, p = 0.003) and total antioxidant capacity (OR 0.93; CI 95%: 0.90–0.96, p <0.001) with prediabetes. Results of the present study suggest that both vitamin E deficiency and oxidative status are associated with prediabetes in apparently healthy subjects.