How do immune response genes work?
Ir genes could operate either by controlling T-cell receptor repertoires, or by controlling antigen presentation to T cells. The idea that Ir genes are a germline set of V genes for T-cell receptors for foreign antigens can be excluded. Models involving indirect control of the T-cell receptor repert...
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| Published in | Immunology today (Amsterdam. Regular ed.) Vol. 1; no. 2; pp. 33 - 36 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
01.08.1980
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| Online Access | Get full text |
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| Summary: | Ir genes could operate either by controlling T-cell receptor repertoires, or by controlling antigen presentation to T cells. The idea that
Ir genes are a germline set of
V genes for T-cell receptors for foreign antigens can be excluded. Models involving indirect control of the T-cell receptor repertoire during somatic generation of diversity are still possible, though evidence from
H-2 mutations suggests that the probability of their being correct is low. The idea that
Ir genes control cell-surface
MHC antigens that must associate closely with foreign antigens in the surface of antigen-presenting cells to cause T-cell activation is compatible with most, if not all of the available data. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0167-5699 |
| DOI: | 10.1016/0167-5699(80)90029-8 |